Human CCL15 Active Protein – Cat# MBS969177

C-C Motif Chemokine 15 Protein (CCL15) Human Active Protein

Name: CCL15 Active Protein; C-C Motif Chemokine 15 Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS969177
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969177

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the… More details

$245 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C-C motif chemokine 15 protein (CCL15), Active Protein

Full Product Name

Recombinant Human C-C motif chemokine 15 protein (CCL15) (Active)

Product Gene Name

CCL15 active protein

Product Synonym Gene Name

MIP5; NCC3; SCYA15

Product Synonym Names

Chemokine CC-2; Leukotactin-1; LKN-1; MIP-1 delta; Macrophage inflammatory protein 5

Sequence

QFINDAETEL MMSKLPLENP VVLNSFHFAA DCCTSYISQS IPCSLMKSYF ETSSECSKPG VIFLTKKGRQ VCAKPSGPGV QDCMKKLKPY SI

Host

E Coli

Form/Format

Lyophilized

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Molecular Weight

10.2 kDa

Sequence Positions

22-113aa

OMIM

U58914 mRNA

3D Structure

ModBase 3D Structure for Q16663

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Homo sapiens (Human)

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Protein Note

Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for CCL15 active protein

Biological Active Protein; Immunology; Chemokine

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CCL15 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL15 purchase

MBS969177 is an active protein targeting CCL15. Also known as Recombinant Human C-C motif chemokine 15 protein (CCL15) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL15. It may not necessarily be applicable to this product.

NCBI GI #

597709818

NCBI GeneID

6359

NCBI Accession #

NP_116741.2

UniProt Primary Accession #

Q16663

UniProt Secondary Accession #

Q9UM74; B2RU34; E1P651

UniProt Related Accession #

Q16663

GenBank Nucleotide #

NM_032965.5

NCBI Official Full Name

C-C motif chemokine 15 preproprotein

NCBI Official Synonym Full Names

C-C motif chemokine ligand 15

NCBI Official Symbol

CCL15

NCBI Official Synonym Symbols

LKN1; NCC3; SY15; HCC-2; LKN-1; MIP-5; NCC-3; SCYL3; MIP-1D; MRP-2B; SCYA15; HMRP-2B; MIP-1 delta

UniProt Protein Name

C-C motif chemokine 15

UniProt Synonym Protein Names

Chemokine CC-2; HCC-2

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL15

UniProt Synonym Gene Names

MIP5; NCC3; SCYA15; HCC-2; LKN-1; MIP-5

NCBI Protein Information

C-C motif chemokine 15

NCBI Summary for CCL15

This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]

UniProt Comments for CCL15

CCL15: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: CCR chemokine receptor binding; chemoattractant activity; chemokine activity; receptor binding

Biological Process: cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity; signal transduction

Research Articles on CCL15

1. CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL15 active protein

Reference Product	PubMed Publications
CCR1 active protein	>31 publications with CCL15 and CCR1
CCR3 active protein	>11 publications with CCL15 and CCR3
CCR2 active protein	>5 publications with CCL15 and CCR2
CCR5 active protein	>4 publications with CCL15 and CCR5
CCR8 active protein	>1 publications with CCL15 and CCR8
CCR7 active protein	>1 publications with CCL15 and CCR7
CCR9 active protein	>1 publications with CCL15 and CCR9

Pathways associated with CCL15 active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with CCL15 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>23 publications with CCL15 and Inflammation
Immune System Diseases Antibodies	>8 publications with CCL15 and Immune System Diseases
Necrosis Antibodies	>8 publications with CCL15 and Necrosis
Carcinoma, Hepatocellular Antibodies	>7 publications with CCL15 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>5 publications with CCL15 and Liver Diseases
Liver Neoplasms Antibodies	>5 publications with CCL15 and Liver Neoplasms
Kidney Diseases Antibodies	>3 publications with CCL15 and Kidney Diseases
Adenocarcinoma Antibodies	>3 publications with CCL15 and Adenocarcinoma
Neoplasm Metastasis Antibodies	>3 publications with CCL15 and Neoplasm Metastasis
Lung Neoplasms Antibodies	>2 publications with CCL15 and Lung Neoplasms

Organs/Tissues associated with CCL15 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>11 publications with CCL15 and Liver
Lung Antibodies	>6 publications with CCL15 and Lung
Kidney Antibodies	>4 publications with CCL15 and Kidney
Intestine Antibodies	>3 publications with CCL15 and Intestine
Brain Antibodies	>2 publications with CCL15 and Brain
Ascites Antibodies	>1 publications with CCL15 and Ascites
Prostate Antibodies	>1 publications with CCL15 and Prostate