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C-C Motif Chemokine 16 Protein (CCL16) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969178

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes,… More details

$245 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C-C motif chemokine 16 protein (CCL16), Active Protein
Full Product Name
Recombinant Human C-C motif chemokine 16 protein (CCL16) (Active)
Product Gene Name
CCL16 active protein
Product Synonym Gene Name
ILINCK; NCC4; SCYA16
Product Synonym Names
Chemokine CC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine
Sequence
QPKVPEWVNT PSTCCLKYYE KVLPRRLVVG YRKALNCHLP AIIFVTKRNR EVCTNPNDDW VQEYIKDPNL PLLPTRNLST VKIITAKNGQ PQLLNSQ
Host
E Coli
Form/Format
Lyophilized
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
Molecular Weight
11.2 kDa
Sequence Positions
24-120aa
OMIM
U91746 mRNA
3D Structure
ModBase 3D Structure for O15467
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Homo sapiens (Human)
Biological Activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 10-100 ng/ml.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Protein Note
Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for CCL16 active protein

Biological Active Protein; Immunology; Chemokine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of CCL16 active protein

Human CCL16 Active Protein – Cat# MBS969178

Other Notes

Small volumes of CCL16 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL16 purchase

MBS969178 is an active protein targeting CCL16. Also known as Recombinant Human C-C motif chemokine 16 protein (CCL16) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL16. It may not necessarily be applicable to this product.

NCBI GI #
4759074
NCBI GeneID
6360
NCBI Accession #
NP_004581.1
UniProt Primary Accession #
O15467
UniProt Secondary Accession #
Q4KKU0
UniProt Related Accession #
O15467
GenBank Nucleotide #
NM_004590.3
NCBI Official Full Name
C-C motif chemokine 16
NCBI Official Synonym Full Names
C-C motif chemokine ligand 16
NCBI Official Symbol
CCL16
NCBI Official Synonym Symbols
LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16
UniProt Protein Name
C-C motif chemokine 16
UniProt Synonym Protein Names
Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL16
UniProt Synonym Gene Names
ILINCK; NCC4; SCYA16; HCC-4; LMC; MTN-1
NCBI Protein Information
C-C motif chemokine 16

NCBI Summary for CCL16

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]
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UniProt Comments for CCL16

CCL16: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; chemoattractant activity; chemokine activity

Biological Process: cell communication; cell-cell signaling; chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity
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Research Articles on CCL16

1. Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL16 active protein

 Reference Product  PubMed Publications
 CCR1 active protein  >17 publications with CCL16 and CCR1
 CCR8 active protein  >8 publications with CCL16 and CCR8
 CCR2 active protein  >7 publications with CCL16 and CCR2
 CCR5 active protein  >7 publications with CCL16 and CCR5
 CCL19 active protein  >2 publications with CCL16 and CCL19
 CXCL6 active protein  >1 publications with CCL16 and CXCL6
 CCL25 active protein  >1 publications with CCL16 and CCL25
 HRH4 active protein  >1 publications with CCL16 and HRH4

Pathways associated with CCL16 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with CCL16 active protein

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >10 publications with CCL16 and Neoplasms, Experimental
 Inflammation Antibodies  >9 publications with CCL16 and Inflammation
 Necrosis Antibodies  >7 publications with CCL16 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with CCL16 and Disease Models, Animal
 Lung Neoplasms Antibodies  >3 publications with CCL16 and Lung Neoplasms
 Liver Diseases Antibodies  >3 publications with CCL16 and Liver Diseases
 Mitochondrial Diseases Antibodies  >1 publications with CCL16 and Mitochondrial Diseases
 Kidney Diseases Antibodies  >1 publications with CCL16 and Kidney Diseases
 Pain Antibodies  >1 publications with CCL16 and Pain
 Colonic Neoplasms Antibodies  >1 publications with CCL16 and Colonic Neoplasms

Organs/Tissues associated with CCL16 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with CCL16 and Liver
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