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C-C Motif Chemokine 4 Protein (CCL4) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969203

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian… More details

$245 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C-C motif chemokine 4 protein (CCL4), Active Protein
Full Product Name
Recombinant Human C-C motif chemokine 4 protein (CCL4) (Active)
Product Gene Name
CCL4 active protein
Product Synonym Gene Name
LAG1; MIP1B; SCYA4
Product Synonym Names
G-26 T-lymphocyte-secreted protein; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta1-69
Sequence
APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
Host
E Coli
Form/Format
Lyophilized
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
Molecular Weight
7.8 kDa
Sequence Positions
24-92aa
OMIM
J04130 mRNA
3D Structure
ModBase 3D Structure for P13236
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Homo sapiens (Human)
Biological Activity
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Protein Note
Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for CCL4 active protein

Biological Active Protein; Immunology; Chemokine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of CCL4 active protein

Human CCL4 Active Protein – Cat# MBS969203

Other Notes

Small volumes of CCL4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL4 purchase

MBS969203 is an active protein targeting CCL4. Also known as Recombinant Human C-C motif chemokine 4 protein (CCL4) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL4. It may not necessarily be applicable to this product.

NCBI GI #
4506845
NCBI GeneID
6351
NCBI Accession #
NP_002975.1
UniProt Primary Accession #
P13236
UniProt Secondary Accession #
P22617; Q13704; Q3SXL8; Q6FGI8
UniProt Related Accession #
P13236
GenBank Nucleotide #
NM_002984.3
NCBI Official Full Name
C-C motif chemokine 4
NCBI Official Synonym Full Names
C-C motif chemokine ligand 4
NCBI Official Symbol
CCL4
NCBI Official Synonym Symbols
ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta
UniProt Protein Name
C-C motif chemokine 4
UniProt Synonym Protein Names
G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL4
UniProt Synonym Gene Names
LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2
NCBI Protein Information
C-C motif chemokine 4

NCBI Summary for CCL4

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

UniProt Comments for CCL4

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemokine activity; cytokine activity; identical protein binding; protein binding

Biological Process: cell adhesion; cell motility; cell-cell signaling; establishment and/or maintenance of cell polarity; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of GTPase activity; response to toxin; response to virus; signal transduction
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Research Articles on CCL4

1. study is the first one to report Ang1 capacity to induce MIP-1beta gene expression, protein synthesis and release from neutrophils, and that these effects are mediated by PI3K, p38 MAPK and MEK activation and downstream NF-kappaB activation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL4 active protein

 Reference Product  PubMed Publications
 CCL3 active protein  >1671 publications with CCL4 and CCL3
 CCR5 active protein  >609 publications with CCL4 and CCR5
 CCR1 active protein  >201 publications with CCL4 and CCR1
 CCR2 active protein  >112 publications with CCL4 and CCR2
 CXCR3 active protein  >76 publications with CCL4 and CXCR3
 CCR3 active protein  >74 publications with CCL4 and CCR3
 CCR7 active protein  >53 publications with CCL4 and CCR7
 CCL17 active protein  >51 publications with CCL4 and CCL17
 IDE active protein  >5 publications with CCL4 and IDE
 CCBP2 active protein  >1 publications with CCL4 and CCBP2

Pathways associated with CCL4 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram

Diseases associated with CCL4 active protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >716 publications with CCL4 and Immune System Diseases
 Disease Progression Antibodies  >265 publications with CCL4 and Disease Progression
 Protein Deficiency Antibodies  >174 publications with CCL4 and Protein Deficiency
 Leukemia Antibodies  >121 publications with CCL4 and Leukemia
 Bone Diseases Antibodies  >111 publications with CCL4 and Bone Diseases
 Hypertension, Portal Antibodies  >103 publications with CCL4 and Hypertension, Portal
 Disease Susceptibility Antibodies  >80 publications with CCL4 and Disease Susceptibility
 Eye Diseases Antibodies  >77 publications with CCL4 and Eye Diseases
 Ischemia Antibodies  >63 publications with CCL4 and Ischemia
 Diabetes Mellitus Antibodies  >55 publications with CCL4 and Diabetes Mellitus

Organs/Tissues associated with CCL4 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4712 publications with CCL4 and Liver
 Blood Antibodies  >3434 publications with CCL4 and Blood
 Bone Marrow Antibodies  >320 publications with CCL4 and Bone Marrow
 Kidney Antibodies  >313 publications with CCL4 and Kidney
 Intestine Antibodies  >130 publications with CCL4 and Intestine
 Lymph Antibodies  >114 publications with CCL4 and Lymph
 Prostate Antibodies  >15 publications with CCL4 and Prostate
 Parathyroid Antibodies  >14 publications with CCL4 and Parathyroid
 Adrenal Gland Antibodies  >7 publications with CCL4 and Adrenal Gland
 Uncharacterized Tissue Antibodies  >1 publications with CCL4 and Uncharacterized Tissue
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