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C-X-C Motif Chemokine 5 Protein (CXCL5) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969230

May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation. {ECO:0000269|PubMed:10570306}. More details

$245 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
C-X-C motif chemokine 5 protein (Cxcl5), Active Protein
Full Product Name
Recombinant Mouse C-X-C motif chemokine 5 protein (Cxcl5) (Active)
Product Gene Name
Cxcl5 active protein
Product Synonym Gene Name
Scyb5
Product Synonym Names
Cytokine LIX;,; GCP-29-78,]
Sequence
APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIQKI LGSDKKKAKR NALAVERTAS VQ
Host
E Coli
Form/Format
Lyophilized
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
Molecular Weight
9.8 kDa
Sequence Positions
41-132aa
3D Structure
ModBase 3D Structure for P50228
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Mus musculus (Mouse)
Biological Activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 10-100 ng/ml.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Protein Note
Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for Cxcl5 active protein

Biological Active Protein; Immunology; Chemokine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of Cxcl5 active protein

Mouse CXCL5 Active Protein – Cat# MBS969230

Other Notes

Small volumes of Cxcl5 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cxcl5 purchase

MBS969230 is an active protein targeting Cxcl5. Also known as Recombinant Mouse C-X-C motif chemokine 5 protein (Cxcl5) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Cxcl5. It may not necessarily be applicable to this product.

NCBI GI #
114842398
NCBI GeneID
20311
NCBI Accession #
NP_033167.2
UniProt Primary Accession #
P50228
UniProt Secondary Accession #
Q8K3I3
UniProt Related Accession #
P50228
GenBank Nucleotide #
NM_009141.3
NCBI Official Full Name
C-X-C motif chemokine 5
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 5
NCBI Official Symbol
Cxcl5
NCBI Official Synonym Symbols
LIX; Cxcl6; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
UniProt Protein Name
C-X-C motif chemokine 5
UniProt Synonym Protein Names
Cytokine LIX; Small-inducible cytokine B5
Protein Family
C-X-C motif chemokine
UniProt Gene Name
Cxcl5
UniProt Synonym Gene Names
Scyb5
NCBI Protein Information
C-X-C motif chemokine 5

NCBI Summary for Cxcl5

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]
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UniProt Comments for Cxcl5

CXCL6: Chemotactic for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5 E1|5 44.78 cM

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: cytokine production; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; leukocyte homeostasis; neutrophil activation; neutrophil chemotaxis; organ regeneration; positive regulation of JAK-STAT cascade; regulation of cell proliferation; regulation of chemokine production; response to lipopolysaccharide
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Research Articles on Cxcl5

1. These data identify suppression of CXCL2 and CXCL5 chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cxcl5 active protein

 Reference Product  PubMed Publications
 Cxcl1 active protein  >247 publications with Cxcl5 and Cxcl1
 Ccl5 active protein  >85 publications with Cxcl5 and Ccl5
 Cxcl10 active protein  >67 publications with Cxcl5 and Cxcl10
 Cxcl9 active protein  >52 publications with Cxcl5 and Cxcl9
 Cxcl3 active protein  >43 publications with Cxcl5 and Cxcl3
 Cxcl12 active protein  >34 publications with Cxcl5 and Cxcl12
 Cxcr3 active protein  >16 publications with Cxcl5 and Cxcr3
 Ccr1 active protein  >8 publications with Cxcl5 and Ccr1
 Ccl9 active protein  >5 publications with Cxcl5 and Ccl9

Pathways associated with Cxcl5 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with Cxcl5 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >274 publications with Cxcl5 and Inflammation
 Necrosis Antibodies  >112 publications with Cxcl5 and Necrosis
 Respiratory Tract Diseases Antibodies  >109 publications with Cxcl5 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >99 publications with Cxcl5 and Lung Diseases
 Disease Models, Animal Antibodies  >79 publications with Cxcl5 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >48 publications with Cxcl5 and Cardiovascular Diseases
 Fibrosis Antibodies  >31 publications with Cxcl5 and Fibrosis
 Liver Diseases Antibodies  >30 publications with Cxcl5 and Liver Diseases
 Pneumonia Antibodies  >29 publications with Cxcl5 and Pneumonia
 Lung Neoplasms Antibodies  >27 publications with Cxcl5 and Lung Neoplasms

Organs/Tissues associated with Cxcl5 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >46 publications with Cxcl5 and Liver
 Intestine Antibodies  >40 publications with Cxcl5 and Intestine
 Eye Antibodies  >19 publications with Cxcl5 and Eye
 Connective Tissue Antibodies  >17 publications with Cxcl5 and Connective Tissue
 Embryonic Tissue Antibodies  >15 publications with Cxcl5 and Embryonic Tissue
 Spleen Antibodies  >10 publications with Cxcl5 and Spleen
 Adipose Tissue Antibodies  >9 publications with Cxcl5 and Adipose Tissue
 Pancreas Antibodies  >6 publications with Cxcl5 and Pancreas
 Mammary Gland Antibodies  >3 publications with Cxcl5 and Mammary Gland
 Vagina Antibodies  >2 publications with Cxcl5 and Vagina
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