Human IL13 Active Protein – Cat# MBS969301

Interleukin-13 Protein (IL13) Human Active Protein

Name: IL13 Active Protein; Interleukin-13 Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS969301
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969301

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. More details

$415 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-13 protein (IL13), Active Protein

Full Product Name

Recombinant Human Interleukin-13 protein (IL13) (Active)

Product Gene Name

IL13 active protein

Product Synonym Gene Name

NC30

Product Synonym Names

IL-13

Sequence

GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN

Host

E Coli

Form/Format

Lyophilized

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Molecular Weight

12.5 kDa

Sequence Positions

35-146aa

OMIM

X69079 mRNA

3D Structure

ModBase 3D Structure for P35225

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Homo sapiens (Human)

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 1 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Protein Note

Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for IL13 active protein

Biological Active Protein; Immunology; Interleukin

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IL13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL13 purchase

MBS969301 is an active protein targeting IL13. Also known as Recombinant Human Interleukin-13 protein (IL13) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL13. It may not necessarily be applicable to this product.

NCBI GI #

26787978

NCBI GeneID

3596

NCBI Accession #

NP_002179.2

UniProt Primary Accession #

P35225

UniProt Secondary Accession #

O43644; Q4VB52; Q9UDC7

UniProt Related Accession #

P35225

GenBank Nucleotide #

NM_002188.2

NCBI Official Full Name

interleukin-13 isoform 1

NCBI Official Synonym Full Names

interleukin 13

NCBI Official Symbol

IL13

NCBI Official Synonym Symbols

P600; IL-13

UniProt Protein Name

Interleukin-13

Protein Family

Interleukin

UniProt Gene Name

IL13

UniProt Synonym Gene Names

NC30; IL-13

NCBI Protein Information

interleukin-13

NCBI Summary for IL13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

UniProt Comments for IL13

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular region; extracellular space

Molecular Function: protein binding

Biological Process: cell motility; cell-cell signaling

Disease: Allergic Rhinitis; Asthma, Susceptibility To

Research Articles on IL13

1. These observations suggest that mechanical stretch may induce an influx of Ca(2+) and up-regulation of IL-13 and MMP-9 expression in 16HBE cells via activation of TRPC1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL13 active protein

Reference Product	PubMed Publications
STAT6 active protein	>440 publications with IL13 and STAT6
IL13RA1 active protein	>300 publications with IL13 and IL13RA1
IL5 active protein	>144 publications with IL13 and IL5
GATA3 active protein	>105 publications with IL13 and GATA3
IL18 active protein	>95 publications with IL13 and IL18
IL4R active protein	>68 publications with IL13 and IL4R
TSLP active protein	>48 publications with IL13 and TSLP
IL3 active protein	>21 publications with IL13 and IL3
VCAM1 active protein	>6 publications with IL13 and VCAM1

Pathways associated with IL13 active protein

Products by Pathway	Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
IL12 Signaling Mediated By STAT4 Pathway antibodies	IL12 Signaling Mediated By STAT4 Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with IL13 active protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>1506 publications with IL13 and Hypersensitivity
Inflammation Antibodies	>1488 publications with IL13 and Inflammation
Asthma Antibodies	>1397 publications with IL13 and Asthma
Hypersensitivity, Immediate Antibodies	>1317 publications with IL13 and Hypersensitivity, Immediate
Lung Diseases Antibodies	>1311 publications with IL13 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>1090 publications with IL13 and Respiratory Hypersensitivity
Necrosis Antibodies	>686 publications with IL13 and Necrosis
Fibrosis Antibodies	>377 publications with IL13 and Fibrosis
Bronchial Hyperreactivity Antibodies	>244 publications with IL13 and Bronchial Hyperreactivity
Dermatitis, Atopic Antibodies	>207 publications with IL13 and Dermatitis, Atopic

Organs/Tissues associated with IL13 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>201 publications with IL13 and Brain
Bone Marrow Antibodies	>159 publications with IL13 and Bone Marrow
Mixed Antibodies	>74 publications with IL13 and Mixed
Testis Antibodies	>8 publications with IL13 and Testis