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Interleukin-17a Protein (IL17A) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969303

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. More details

$245 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-17A protein (IL17A), Active Protein
Full Product Name
Recombinant Human Interleukin-17A protein (IL17A) (Active)
Product Gene Name
IL17A active protein
Product Synonym Gene Name
CTLA8; IL17
Product Synonym Names
IL-17; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Sequence
GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA
Host
E Coli
Form/Format
Lyophilized
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
Molecular Weight
31.0 kDa
Sequence Positions
24-155aa
OMIM
Z58820 mRNA
3D Structure
ModBase 3D Structure for Q16552
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Homo sapiens (Human)
Biological Activity
Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of > 1.3 × 105 IU/mg.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Protein Note
Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for IL17A active protein

Biological Active Protein; Immunology; Interleukin
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IL17A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17A purchase

MBS969303 is an active protein targeting IL17A. Also known as Recombinant Human Interleukin-17A protein (IL17A) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17A. It may not necessarily be applicable to this product.

NCBI GI #
4504651
NCBI GeneID
3605
NCBI Accession #
NP_002181.1
UniProt Primary Accession #
Q16552
UniProt Secondary Accession #
Q5T2P0
UniProt Related Accession #
Q16552
GenBank Nucleotide #
NM_002190.2
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; CTLA-8; IL-17A
UniProt Protein Name
Interleukin-17A
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family
Interleukin
UniProt Gene Name
IL17A
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8
NCBI Protein Information
interleukin-17A

NCBI Summary for IL17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL17A

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12.2

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Process: apoptosis; cell death; cell-cell signaling; immune response; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter
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Research Articles on IL17A

1. exogenous IL-17A is stored in intracellular granules and can subsequently be released in a bioactive form

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL17A active protein

 Reference Product  PubMed Publications
 FOXP3 active protein  >82 publications with IL17A and FOXP3
 IL6 active protein  >69 publications with IL17A and IL6
 STAT3 active protein  >41 publications with IL17A and STAT3
 IL17RA active protein  >32 publications with IL17A and IL17RA
 IL22 active protein  >25 publications with IL17A and IL22
 TGFB1 active protein  >22 publications with IL17A and TGFB1
 STAT1 active protein  >15 publications with IL17A and STAT1
 IL17RC active protein  >11 publications with IL17A and IL17RC
 TRAF3IP2 active protein  >6 publications with IL17A and TRAF3IP2
 NFKB1 active protein  >4 publications with IL17A and NFKB1

Pathways associated with IL17A active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL17 Signaling Pathway antibodies  IL17 Signaling Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram

Diseases associated with IL17A active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >372 publications with IL17A and Inflammation
 Autoimmune Diseases Antibodies  >199 publications with IL17A and Autoimmune Diseases
 Disease Models, Animal Antibodies  >158 publications with IL17A and Disease Models, Animal
 Necrosis Antibodies  >125 publications with IL17A and Necrosis
 Lung Diseases Antibodies  >108 publications with IL17A and Lung Diseases
 Hypersensitivity Antibodies  >64 publications with IL17A and Hypersensitivity
 Cardiovascular Diseases Antibodies  >59 publications with IL17A and Cardiovascular Diseases
 Colitis Antibodies  >52 publications with IL17A and Colitis
 Central Nervous System Diseases Antibodies  >52 publications with IL17A and Central Nervous System Diseases
 Fibrosis Antibodies  >31 publications with IL17A and Fibrosis

Organs/Tissues associated with IL17A active protein

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >16 publications with IL17A and Mixed
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