Human AIMP1 Active Protein – Cat# MBS969346

Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1 Protein (AIMP1) Human Active Protein

Name: AIMP1 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS969346
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969346

$245 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 protein (AIMP1), Active Protein

Full Product Name

Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 protein (AIMP1) (Active)

Product Gene Name

AIMP1 active protein

Product Synonym Gene Name

EMAP2; SCYE1

Product Synonym Names

Multisynthase complex auxiliary component p43; Endothelial monocyte-activating polypeptide II; EMAP-II; Small i

Sequence

SKPIDVSRLD LRIGCIITAR KHPDADSLYV EEVDVGEIAP RTVVSGLVNH VPLEQMQNRM VILLCNLKPA KMRGVLSQAM VMCASSPEKI EILAPPNGSV PGDRITFDAF PGEPDKELNP KKKIWEQIQP DLHTNDECVA TYKGVPFEVK GKGVCRAQTM SNSGIK

Host

E Coli

Form/Format

Lyophilized

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Molecular Weight

18.2 kDa

Sequence Positions

147-312aa

OMIM

U10117 mRNA

3D Structure

ModBase 3D Structure for Q12904

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Homo sapiens (Human)

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by the apoptotic effect using serum free human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of > 2.5 × 104 IU/mg.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Protein Note

Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for AIMP1 active protein

Biological Active Protein; Cancer

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of AIMP1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIMP1 purchase

MBS969346 is an active protein targeting AIMP1. Also known as Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 protein (AIMP1) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AIMP1. It may not necessarily be applicable to this product.

NCBI GI #

215490009

NCBI GeneID

9255

NCBI Accession #

NP_001135887.1

UniProt Primary Accession #

Q12904

UniProt Secondary Accession #

Q6FG28; Q96CQ9; B3KTR2; B4E1S7

UniProt Related Accession #

Q12904

GenBank Nucleotide #

NM_001142415.1

NCBI Official Full Name

aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a

NCBI Official Synonym Full Names

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

NCBI Official Symbol

AIMP1

NCBI Official Synonym Symbols

p43; HLD3; EMAP2; SCYE1; EMAPII

UniProt Protein Name

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

UniProt Synonym Protein Names

Multisynthase complex auxiliary component p43

Protein Family

Aminoacyl tRNA synthase complex-interacting multifunctional protein

UniProt Gene Name

AIMP1

UniProt Synonym Gene Names

EMAP2; SCYE1; EMAP-2; EMAP-II

NCBI Protein Information

aminoacyl tRNA synthase complex-interacting multifunctional protein 1

NCBI Summary for AIMP1

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

UniProt Comments for AIMP1

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Research Articles on AIMP1

1. p43 induces both the mRNA and protein expression of IP-10.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AIMP1 active protein

Reference Product	PubMed Publications
AIMP2 active protein	>9 publications with AIMP1 and AIMP2
EPRS active protein	>3 publications with AIMP1 and EPRS
LARS active protein	>2 publications with AIMP1 and LARS
KARS active protein	>2 publications with AIMP1 and KARS
RARS active protein	>2 publications with AIMP1 and RARS
MARS active protein	>2 publications with AIMP1 and MARS
DARS active protein	>1 publications with AIMP1 and DARS
IARS active protein	>1 publications with AIMP1 and IARS
EEF1E1 active protein	>1 publications with AIMP1 and EEF1E1
QARS active protein	>1 publications with AIMP1 and QARS

Pathways associated with AIMP1 active protein

Products by Pathway	Pathway Diagram
Cytosolic TRNA Aminoacylation Pathway antibodies	Cytosolic TRNA Aminoacylation Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
SeMet Incorporation Into Proteins Pathway antibodies	SeMet Incorporation Into Proteins Pathway Diagram
Selenoamino Acid Metabolism Pathway antibodies	Selenoamino Acid Metabolism Pathway Diagram
TRNA Aminoacylation Pathway antibodies	TRNA Aminoacylation Pathway Diagram

Diseases associated with AIMP1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>9 publications with AIMP1 and Inflammation
Atrophy Antibodies	>2 publications with AIMP1 and Atrophy
Fibrosis Antibodies	>2 publications with AIMP1 and Fibrosis
Liver Diseases Antibodies	>1 publications with AIMP1 and Liver Diseases
Breast Neoplasms Antibodies	>1 publications with AIMP1 and Breast Neoplasms
Nervous System Malformations Antibodies	>1 publications with AIMP1 and Nervous System Malformations
Congenital Abnormalities Antibodies	>1 publications with AIMP1 and Congenital Abnormalities
Hyperplasia Antibodies	>1 publications with AIMP1 and Hyperplasia
Necrosis Antibodies	>1 publications with AIMP1 and Necrosis

Organs/Tissues associated with AIMP1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with AIMP1 and Blood
Lung Antibodies	>4 publications with AIMP1 and Lung
Bone Antibodies	>4 publications with AIMP1 and Bone
Stomach Antibodies	>3 publications with AIMP1 and Stomach
Vascular Antibodies	>3 publications with AIMP1 and Vascular
Brain Antibodies	>3 publications with AIMP1 and Brain
Muscle Antibodies	>2 publications with AIMP1 and Muscle
Liver Antibodies	>2 publications with AIMP1 and Liver
Intestine Antibodies	>2 publications with AIMP1 and Intestine
Spleen Antibodies	>2 publications with AIMP1 and Spleen