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Fibroblast Growth Factor 4 Protein (FGF4) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969359

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. {ECO:0000269|PubMed:8663044}. More details

$245 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fibroblast growth factor 4 protein (FGF4), Active Protein
Full Product Name
Recombinant Human Fibroblast growth factor 4 protein (FGF4) (Active)
Product Gene Name
FGF4 active protein
Product Synonym Gene Name
HST; HSTF1; KS3
Product Synonym Names
FGF-4; HST; HST-1; HSTF-1; Heparin-binding growth factor 4
Sequence
GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL
Host
E Coli
Form/Format
Lyophilized
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
Molecular Weight
19.8 kDa
Sequence Positions
25-206aa
OMIM
FJ456981 mRNA
3D Structure
ModBase 3D Structure for P08620
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Homo sapiens (Human)
Biological Activity
Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 106 IU/mg.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Protein Note
Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for FGF4 active protein

Biological Active Protein; Cancer; Growth Factor
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of FGF4 active protein

Human FGF4 Active Protein – Cat# MBS969359

Other Notes

Small volumes of FGF4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF4 purchase

MBS969359 is an active protein targeting FGF4. Also known as Recombinant Human Fibroblast growth factor 4 protein (FGF4) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF4. It may not necessarily be applicable to this product.

NCBI GI #
4503701
NCBI GeneID
2249
NCBI Accession #
NP_001998.1
UniProt Primary Accession #
P08620
UniProt Secondary Accession #
B7U994
UniProt Related Accession #
P08620; AAB21430
GenBank Nucleotide #
NM_002007.3
NCBI Official Full Name
fibroblast growth factor 4
NCBI Official Synonym Full Names
fibroblast growth factor 4
NCBI Official Symbol
FGF4
NCBI Official Synonym Symbols
HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1
UniProt Protein Name
Fibroblast growth factor 4
UniProt Synonym Protein Names
Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF4
UniProt Synonym Gene Names
HST; HSTF1; KS3; FGF-4; HST; HST-1; HSTF-1; HBGF-4
NCBI Protein Information
fibroblast growth factor 4

NCBI Summary for FGF4

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF4

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Research Articles on FGF4

1. Thus, we conclude that the oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Therapeutically, HBXIP may serve as a novel target in breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF4 active protein

 Reference Product  PubMed Publications
 SHH active protein  >80 publications with FGF4 and SHH
 FGFR2 active protein  >53 publications with FGF4 and FGFR2
 FGFR1 active protein  >43 publications with FGF4 and FGFR1
 BMP4 active protein  >41 publications with FGF4 and BMP4
 CDX2 active protein  >19 publications with FGF4 and CDX2
 FGFR3 active protein  >18 publications with FGF4 and FGFR3
 FGFR4 active protein  >18 publications with FGF4 and FGFR4
 LEF1 active protein  >12 publications with FGF4 and LEF1
 MYF5 active protein  >7 publications with FGF4 and MYF5
 MYOG active protein  >3 publications with FGF4 and MYOG

Pathways associated with FGF4 active protein

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with FGF4 active protein

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >41 publications with FGF4 and Skin Diseases
 Breast Neoplasms Antibodies  >41 publications with FGF4 and Breast Neoplasms
 Disease Models, Animal Antibodies  >26 publications with FGF4 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >26 publications with FGF4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >22 publications with FGF4 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >16 publications with FGF4 and Neoplasms, Experimental
 Brain Diseases Antibodies  >14 publications with FGF4 and Brain Diseases
 Abnormalities, Multiple Antibodies  >11 publications with FGF4 and Abnormalities, Multiple
 Carcinoma, Hepatocellular Antibodies  >11 publications with FGF4 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >10 publications with FGF4 and Necrosis

Organs/Tissues associated with FGF4 active protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >143 publications with FGF4 and Embryonic Tissue
 Testis Antibodies  >11 publications with FGF4 and Testis
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