Proheparin-Binding EGF-Like Growth Factor [Cleaved Into: Heparin-Binding EGF-Like Growth Factor Protein (HBEGF) Human Active Protein

HBEGF: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cell surface; extracellular region; extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: epidermal growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: epidermal growth factor receptor signaling pathway; MAPKKK cascade; muscle development; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; regulation of phosphoinositide 3-kinase cascade; signal transduction