Mouse IL3 Active Protein – Cat# MBS969447

Interleukin-3 Protein (IL3) Mouse Active Protein

Name: IL3 Active Protein; Interleukin-3 Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS969447
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969447

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.; This CSF… More details

$415 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-3 protein (Il3), Active Protein

Full Product Name

Recombinant Mouse Interleukin-3 protein (Il3) (Active)

Product Gene Name

Il3 active protein

Product Synonym Gene Name

Csfmu; Il-3

Product Synonym Names

IL-3; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor

Sequence

DTHRLTRTLN CSSIVKEIIG KLPEPELKTD DEGPSLRNKS FRRVNLSKFV ESQGEVDPED RYVIKSNLQK LNCCLPTSAN DSALPGVFIR DLDDFRKKLR FYMVHLNDLE TVLTSRPPQP ASGSVSPNRG TVEC

Host

E Coli

Form/Format

Lyophilized

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Molecular Weight

14.8 kDa

Sequence Positions

33-166aa

3D Structure

ModBase 3D Structure for P01586

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Mus musculus (Mouse)

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is less than 0.05 ng/ml, corresponding to a specific activity of > 2 × 107 IU/mg.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Protein Note

Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for Il3 active protein

Biological Active Protein; Immunology; Interleukin

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Il3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il3 purchase

MBS969447 is an active protein targeting Il3. Also known as Recombinant Mouse Interleukin-3 protein (Il3) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Il3. It may not necessarily be applicable to this product.

NCBI GI #

31982791

NCBI GeneID

16187

NCBI Accession #

NP_034686.2

UniProt Primary Accession #

P01586

UniProt Related Accession #

P01586

GenBank Nucleotide #

NM_010556.4

NCBI Official Full Name

interleukin-3

NCBI Official Synonym Full Names

interleukin 3

NCBI Official Symbol

Il3

NCBI Official Synonym Symbols

BPA; PSF; HCGF; Il-3; MCGF; Csfmu

UniProt Protein Name

Interleukin-3

UniProt Synonym Protein Names

Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor

Protein Family

Interleukin

UniProt Gene Name

Il3

UniProt Synonym Gene Names

Csfmu; Il-3; IL-3; MCGF

NCBI Protein Information

interleukin-3

UniProt Comments for Il3

IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.

Protein type: Apoptosis; Cell cycle regulation; Cytokine; Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 B1.3|11 32.13 cM

Cellular Component: extracellular space

Molecular Function: cytokine activity; growth factor activity; interleukin-1 receptor binding; interleukin-3 receptor binding

Biological Process: activation of JAK protein; cytokine and chemokine mediated signaling pathway; fever; hemopoiesis; monocyte differentiation; myeloid cell apoptosis; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of mast cell apoptosis; positive regulation of cell proliferation; positive regulation of JNK cascade; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; regulation of cell growth; regulation of gene expression; regulation of glycolysis; regulation of protein amino acid dephosphorylation; response to hormone stimulus; response to hypoxia

Research Articles on Il3

1. IL-3 signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Il3 active protein

Reference Product	PubMed Publications
Il2 active protein	>86 publications with Il3 and Il2
Csf2 active protein	>15 publications with Il3 and Csf2
Il7 active protein	>11 publications with Il3 and Il7
Csf2rb active protein	>10 publications with Il3 and Csf2rb
Il5ra active protein	>6 publications with Il3 and Il5ra
Mpl active protein	>5 publications with Il3 and Mpl
Jak3 active protein	>2 publications with Il3 and Jak3

Pathways associated with Il3 active protein

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Signaling Pathway antibodies	Apoptosis Signaling Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with Il3 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>33 publications with Il3 and Necrosis
Lung Diseases Antibodies	>26 publications with Il3 and Lung Diseases
Inflammation Antibodies	>24 publications with Il3 and Inflammation
Neoplasms, Experimental Antibodies	>19 publications with Il3 and Neoplasms, Experimental
Asthma Antibodies	>19 publications with Il3 and Asthma
Anemia Antibodies	>13 publications with Il3 and Anemia
Nervous System Diseases Antibodies	>12 publications with Il3 and Nervous System Diseases
Lung Neoplasms Antibodies	>6 publications with Il3 and Lung Neoplasms
Skin Neoplasms Antibodies	>6 publications with Il3 and Skin Neoplasms
Kidney Diseases Antibodies	>6 publications with Il3 and Kidney Diseases

Organs/Tissues associated with Il3 active protein

Organ/Tissue Name	Pubmed Publications
Thymus Antibodies	>15 publications with Il3 and Thymus
Embryonic Tissue Antibodies	>5 publications with Il3 and Embryonic Tissue