Human FKBP3 Recombinant Protein – Cat# MBS969523

Peptidyl-Prolyl Cis-Trans Isomerase FKBP3 (FKBP3) Human Recombinant Protein

Name: FKBP3 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS969523
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969523

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. More details

$440 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Peptidyl-prolyl cis-trans isomerase FKBP3, Recombinant Protein

Full Product Name

Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP3

Product Gene Name

FKBP3 recombinant protein

Product Synonym Names

25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase

Sequence

AAAVPQRAWT VEQLRSEQLP KKDIIKFLQE HGSDSFLAEH KLLGNIKNVA KTANKDHLVT AYNHLFETKR FKGTESISKV SEQVKNVKLN EDKPKETKSE ETLDEGPPKY TKSVLKKGDK TNFPKKGDVV HCWYTGTLQD GTVFDTNIQT SAKKKKNAKP LSFKVGVGKV IRGWDEALLT MSKGEKARLE IEPEWAYGKK GQPDAKIPPN AKLTFEVELV DID

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

41 kDa

Sequence Positions

2-224aa; Full-Length of the Mature

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

186947

3D Structure

ModBase 3D Structure for Q00688

Product Categories/Family for FKBP3 recombinant protein

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for FKBP3 recombinant protein

Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein.Wiederrecht G., Martin M., Sigal N., Siekierka J.J.Biochem. Biophys. Res. Commun. 185:298-303(1992)

Other Notes

Small volumes of FKBP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP3 purchase

MBS969523 is a recombinant protein targeting FKBP3. Also known as Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP3. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP3. It may not necessarily be applicable to this product.

NCBI GI #

4503727

NCBI GeneID

2287

NCBI Accession #

NP_002004.1

UniProt Primary Accession #

Q00688

UniProt Secondary Accession #

Q14317; B2R4Q9

UniProt Related Accession #

Q00688

GenBank Nucleotide #

NM_002013.3

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase FKBP3

NCBI Official Synonym Full Names

FK506 binding protein 3

NCBI Official Symbol

FKBP3

NCBI Official Synonym Symbols

FKBP-3; FKBP25; PPIase; FKBP-25

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP3

UniProt Synonym Protein Names

25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase

Protein Family

FK506-binding protein

UniProt Gene Name

FKBP3

UniProt Synonym Gene Names

FKBP25; PPIase FKBP3; 25 kDa FKBP; FKBP-25; FKBP-3

UniProt Entry Name

FKBP3_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP3

NCBI Summary for FKBP3

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

UniProt Comments for FKBP3

FKBP3: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Belongs to the FKBP-type PPIase family.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: endoplasmic reticulum membrane; nucleus

Molecular Function: FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; receptor activity

Biological Process: protein peptidyl-prolyl isomerization

Research Articles on FKBP3

1. proteomics study indicates that the nuclear pool of the FKBP25 targets various nuclear proteins that are crucial for packaging of DNA, chromatin remodeling and pre-mRNA splicing

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBP3 recombinant protein

Reference Product	PubMed Publications
YY1 recombinant protein	>2 publications with FKBP3 and YY1
LARP6 recombinant protein	>1 publications with FKBP3 and LARP6
HDAC1 recombinant protein	>1 publications with FKBP3 and HDAC1
HDAC2 recombinant protein	>1 publications with FKBP3 and HDAC2

Pathways associated with FKBP3 recombinant protein

Products by Pathway	Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Signaling Events Mediated By HDAC Class I Pathway antibodies	Signaling Events Mediated By HDAC Class I Pathway Diagram

Diseases associated with FKBP3 recombinant protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>1 publications with FKBP3 and Immune System Diseases
Liver Diseases Antibodies	>1 publications with FKBP3 and Liver Diseases
Inflammation Antibodies	>1 publications with FKBP3 and Inflammation

Organs/Tissues associated with FKBP3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with FKBP3 and Brain
Liver Antibodies	>2 publications with FKBP3 and Liver
Ovary Antibodies	>1 publications with FKBP3 and Ovary
Eye Antibodies	>1 publications with FKBP3 and Eye
Heart Antibodies	>1 publications with FKBP3 and Heart
Blood Antibodies	>1 publications with FKBP3 and Blood
Muscle Antibodies	>1 publications with FKBP3 and Muscle
Embryonic Tissue Antibodies	>1 publications with FKBP3 and Embryonic Tissue