Transcription Initiation Factor IIB (GTF2B) Human Recombinant Protein

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Cloning of a human gene encoding the general transcription initiation factor IIB.Ha I., Lane W.S., Reinberg D.Nature 352:689-695(1991) Sequence of general transcription factor TFIIB and relationships to other initiation factors.Malik S., Hisatake K., Sumimoto H., Horikoshi M., Roeder R.G.Proc. Natl. Acad. Sci. 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Methods 5:1011-1017(2008) The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.Nature 441:315-321(2006) Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II) .Ing N.H., Beekman J.M., Tsai S.Y., Tsai M.J., O'Malley B.W.J. Biol. Chem. 267:17617-17623(1992) ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.Smith C.A., Bates P., Rivera-Gonzalez R., Gu B., DeLuca N.A.J. Virol. 67:4676-4687(1993) Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II.Umehara T., Kida S., Yamamoto T., Horikoshi M.Gene 167:297-302(1995) The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein.Tong X., Wang F., Thut C.J., Kieff E.J. Virol. 69:585-588(1995) The human immunodeficiency virus type 1 Vpr transactivator cooperation with promoter-bound activator domains and binding to TFIIB.Agostini I., Navarro J.-M., Rey F., Bouhamdan M., Spire B., Vigne R., Sire J.J. Mol. Biol. 261:599-606(1996) The HIV-1 Vpr co-activator induces a conformational change in TFIIB.Agostini I., Navarro J.M., Bouhamdan M., Willetts K., Rey F., Spire B., Vigne R., Pomerantz R., Sire J.FEBS Lett. 450:235-239(1999) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) Solution structure of the C-terminal core domain of human TFIIB similarity to cyclin A and interaction with TATA-binding protein.Bagby S., Kim S., Maldonado E., Tong K.I., Reinberg D., Ikura M.Cell 82:857-867(1995) Crystal structure of a TFIIB-TBP-TATA-element ternary complex.Nikolov D.B., Chen H., Halay E.D., Usheva A.A., Hisatake K., Lee D.K., Roeder R.G., Burley S.K.Nature 377:119-128(1995) Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription.Chen H.T., Legault P., Glushka J., Omichinski J.G., Scott R.A.Protein Sci. 9:1743-1752(2000) The consensus coding sequences of human breast and colorectal cancers.Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.Science 314:268-274(2006) +Additional computationally mapped references.<p>Provides general information on the entry.

Small volumes of GTF2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS969533 is a recombinant protein targeting GTF2B. Also known as Recombinant Human Transcription initiation factor IIB. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.