NADPH Oxidase 4 (NOX4) Rat Recombinant Protein

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.

Novel gp91(phox) homologues in vascular smooth muscle cells nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways.Lassegue B., Sorescu D., Szoecs K., Yin Q., Akers M., Zhang Y., Grant S.L., Lambeth J.D., Griendling K.K.Circ. Res. 88:888-894(2001) A novel superoxide-producing NAD(P) H oxidase in kidney.Shiose A., Kuroda J., Tsuruya K., Hirai M., Hirakata H., Naito S., Hattori M., Sakaki Y., Sumimoto H.J. Biol. Chem. 276:1417-1423(2001) Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells.Hilenski L.L., Clempus R.E., Quinn M.T., Lambeth J.D., Griendling K.K.Arterioscler. Thromb. Vasc. Biol. 24:677-683(2004) Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.Ambasta R.K., Kumar P., Griendling K.K., Schmidt H.H.H.W., Busse R., Brandes R.P.J. Biol. Chem. 279:45935-45941(2004) Nox4 NAD(P) H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney.Gorin Y., Block K., Hernandez J., Bhandari B., Wagner B., Barnes J.L., Abboud H.E.J. Biol. Chem. 280:39616-39626(2005) Regulation of NAD(P) H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells.Janiszewski M., Lopes L.R., Carmo A.O., Pedro M.A., Brandes R.P., Santos C.X.C., Laurindo F.R.M.J. Biol. Chem. 280:40813-40819(2005)

Small volumes of Nox4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS969581 is a recombinant protein targeting Nox4. Also known as Recombinant Rat NADPH oxidase 4. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.