Lipase, Bile Salt Dependent (BSDL) ELISA Kit for Mouse

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Lipid Metabolism - steroid biosynthesis; EC 3.1.1.13; Lipid Metabolism - glycerolipid; Lipase; EC 3.1.1.3

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: sterol esterase activity; heparin binding; triacylglycerol lipase activity; protein binding; hydrolase activity; acylglycerol lipase activity; catalytic activity

Biological Process: intestinal lipid catabolic process; triacylglycerol metabolic process; cholesterol absorption; fatty acid catabolic process; lipid metabolic process; pancreatic juice secretion; protein amino acid esterification; cholesterol catabolic process; lipid digestion

Disease: Maturity-onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction