BZW2 ELISA Kits

A study shows that the homo sapiens basic leucine zipper and W2 domains 1 (BZW1 or BZAP45) is a critical factor in the regulation of mucoepidermoid carcinoma (MEC) growth. Firstly, BZW1 was highly expressed in MEC tissues and cells, determined by quantitative real time polymerase chain reaction. Higher levels of BZW1 proteins were detected in MEC tissues, particularly in high-grade MEC, by immunohistochemistry. Importantly, down-regulation of BZW1 expression significantly reduced the tumorigenicity of Mc3 cells in vivo, evidenced by the slow progression of small tumors induced by BZW1-specific RNAi expressing Mc3 cells. Apparently, BZW1 is a novel factor, promoting the growth of MEC cells. The findings may provide a base for design of new strategy for diagnosis and therapy for human MEC.

The levels of eukaryotic translation initiation factors 1 (eIF1) and 5 (eIF5) play critical roles in controlling the stringency of translation start site selection. The basic leucine zipper and W2 domain-containing proteins 1 and 2 (BZW1 and BZW2), also known as eIF5-mimic proteins, are paralogous human proteins containing C-terminal HEAT domains that resemble the HEAT domain of eIF5. A study shows that translation of mRNAs encoding BZW1 and BZW2 homologs in fungi, plants and metazoans is initiated by AUG codons in conserved unfavorable initiation contexts. The study shows that overexpression of BZW1 and BZW2 proteins enhance the stringency of start site selection, and that their poor initiation codons confer autoregulation on BZW1 and BZW2 mRNA translation. The results reveal a surprising role for BZW1 and BZW2 in maintaining homeostatic stringency of start codon selection and suggest a model for BZW1 and BZW2 function.