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C4a native protein :: Complement C4 Native Protein

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Catalog # MBS536517
Unit / Price
  10 mg  /  $2,555 +3 FREE 8GB USB
C4a native protein
Product Name

Complement C4 (C4a), Native Protein

Also Known As

Complement C4 protein

Product Synonym Names
C4 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1737
3D Structure
ModBase 3D Structure for P08649
Host
Human
Purity/Purification
> 99% pure
Form/Format
Na3PO4 buffer, pH 7.0, with 150mM NaCl, and 0.09% NaN3.
Source Note
Human plasma
Protein Type
Native
Biological Significance
Component C4 interacts with C1 and C2 to form C3 convertase of the classic activation pathway. Systemic lupus erythematosus (SLE) is often associated with congenital C4 deficiency. Reduced levels of components of the classic pathway (C1, C2, C4, C3) are common after such activation, e.g. in SLE, acute serum sickness and conditions associated with circulating immune complexes. The common form present in plasma and used in diagnostics assays is the C4c form offered here.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
Other Notes
Small volumes of C4a native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
C4a native protein
Purified Complement C4 protein isolated from human plasma
NCBI/Uniprot data below describe general gene information for C4a. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
complement C4
NCBI Official Synonym Full Names
complement component 4A (Rodgers blood group)
NCBI Official Symbol
NCBI Official Synonym Symbols
C4; C4b; C4-1
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NCBI Protein Information
complement C4
UniProt Protein Name
Complement C4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
CO4_RAT
NCBI Summary for C4a
complement protein, part of the classical activation pathway; localizes to the class III region of the MHC [RGD, Feb 2006]
UniProt Comments for C4a
C4A: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function: complement component C1q binding; endopeptidase inhibitor activity

Biological Process: innate immune response; inflammatory response; complement activation, classical pathway; complement activation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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