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Eotaxin (CCL11) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142017

Description: Eotaxin Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8403.2 Dalton. The CCL11 is purified by proprietary chromatographic techniques.Introduction:… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Eotaxin (Ccl11), Active Protein
Full Product Name
Recombinant Mouse Eotaxin (CCL11)
Product Gene Name
Ccl11 active protein
Product Synonym Names
Eotaxin Mouse; Eotaxin Mouse Recombinant (CCL11); Small inducible cytokine A11; CCL11; Eosinophil chemotactic protein; chemokine (C-C motif) ligand 11; SCYA11; mEotaxin
Sequence
The sequence of the first five N-terminal amino acids was determined and was found to be His-Pro-Gl y-Ser-Ile
Host
E Coli
Form/Format
Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Preparation and Storage
Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL11 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Molecular Weight
10,893 Da
3D Structure
ModBase 3D Structure for P48298
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized Eotaxin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The Biological activity was determined by measuring the dose dependent phosphorylation of ERK1 and ERK2 in CCR3 transfected 293 cells. Significant ERK phosphorylation is observed with >100 ng/ml (corresponding to a Specific Activity of 10,000IU/mg) of recombinant mouse eotaxin.

Product Categories/Family for Ccl11 active protein

Chemokines; Eotaxin

Other Notes

Small volumes of Ccl11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ccl11 purchase

MBS142017 is an active protein targeting Ccl11. Also known as Recombinant Mouse Eotaxin (CCL11). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Ccl11. It may not necessarily be applicable to this product.

NCBI GI #
6755418
NCBI GeneID
20292
NCBI Accession #
NP_035460.1
UniProt Primary Accession #
P48298
UniProt Related Accession #
P48298
GenBank Nucleotide #
NM_011330.3
NCBI Official Full Name
eotaxin
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 11
NCBI Official Symbol
Ccl11
NCBI Official Synonym Symbols
Scya11; eotaxin
UniProt Protein Name
Eotaxin
UniProt Synonym Protein Names
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Protein Family
Eotaxin
UniProt Gene Name
Ccl11
UniProt Synonym Gene Names
Scya11
UniProt Entry Name
CCL11_MOUSE
NCBI Protein Information
eotaxin; C-C motif chemokine 11; eosinophil chemotactic protein; small chemokine (C-C motif) ligand 11; small inducible cytokine A11; small-inducible cytokine A11

UniProt Comments for Ccl11

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function: chemokine activity; cytokine activity

Biological Process: regulation of cell shape; positive regulation of angiogenesis; positive regulation of actin filament polymerization; mast cell chemotaxis; eosinophil chemotaxis; actin filament organization; immune response; cytoskeleton organization and biogenesis; positive regulation of endothelial cell proliferation; chemotaxis; inflammatory response; positive regulation of cell migration
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Research Articles on Ccl11

1. Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ccl11 active protein

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram

Diseases associated with Ccl11 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >703 publications with Ccl11 and Inflammation
 Respiratory Tract Diseases Antibodies  >573 publications with Ccl11 and Respiratory Tract Diseases
 Hypersensitivity Antibodies  >565 publications with Ccl11 and Hypersensitivity
 Asthma Antibodies  >511 publications with Ccl11 and Asthma
 Lung Diseases Antibodies  >470 publications with Ccl11 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >411 publications with Ccl11 and Respiratory Hypersensitivity
 Necrosis Antibodies  >196 publications with Ccl11 and Necrosis
 Bronchial Hyperreactivity Antibodies  >86 publications with Ccl11 and Bronchial Hyperreactivity
 Drug Hypersensitivity Antibodies  >82 publications with Ccl11 and Drug Hypersensitivity
 Dermatitis, Atopic Antibodies  >60 publications with Ccl11 and Dermatitis, Atopic

Organs/Tissues associated with Ccl11 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >487 publications with Ccl11 and Lung
 Intestine Antibodies  >56 publications with Ccl11 and Intestine
 Eye Antibodies  >50 publications with Ccl11 and Eye
 Thymus Antibodies  >28 publications with Ccl11 and Thymus
 Embryonic Tissue Antibodies  >12 publications with Ccl11 and Embryonic Tissue
 Mixed Antibodies  >10 publications with Ccl11 and Mixed
 Mammary Gland Antibodies  >3 publications with Ccl11 and Mammary Gland
 Tongue Antibodies  >2 publications with Ccl11 and Tongue
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