CZF1 ELISA Kits

Zinc-binding proteins form one of the largest families of transcriptional regulators in eukaryotes, displaying variable secondary structures and enormous functional diversity. The trace element zinc is required for proper function of a large number of proteins, including various enzymes. Most zinc-containing proteins are transcription factors capable of binding DNA and are named zinc finger proteins. The family of zinc cluster proteins is best characterized for the budding yeast, Saccharomyces cerevisiae. The genome of this organism encodes over 50 known (or putative) zinc cluster proteins.

The finger actually consists of one _ helix and a pair of antiparallel _ strands. In general, one or more zinc atoms are bound by cysteine or histidine residues. This stabilizes the domain and contributes to proper protein structure and function. The majority of zinc finger proteins bind to nucleic acid thereby playing important roles in transcriptional and translational processes. However, this superfamily of proteins are also involved in many other physiological roles, including mediating protein-protein interactions, chromatin remodeling, protein chaperoning, lipid binding, and zinc sensing. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor of beta-glucan synthesis, thus negatively regulating cell wall integrity. Plays a role in adherence, invasion and damage to oral epithelial cells.