DDC Recombinant Protein – Cat# MBS203181

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Dopa Decarboxylase (DDC) Recombinant Protein

Name: DDC Recombinant Protein; Dopa Decarboxylase; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203181
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203181

Dopa decarboxylase, also known as DDC, is a homodimeric, pyridoxal phosphate dependent enzyme. Dopa decarboxylase is a protein implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dopa decarboxylase (DDC), Recombinant Protein

Full Product Name

Dopa decarboxylase, 1-480aa, Human, His tag, E Coli

Product Gene Name

DDC recombinant protein

Product Synonym Names

DDC; AADC; Aromatic L-amino acid decarboxylase; L-Dopa decarboxylase; Aromatic L Amino Acid Decarboxylase

Sequence

< MGSSHHHHHH SSGLVPRGSH TRSMNASEFR RRGKEMVDYV ANYMEGIEGR QVYPDVEPGY LRPLIPAAAP QEPDTFEDII NDVEKIIMPG VTHWHSPYFF AYFPTASSYP AMLADMLCGA IGCIGFSWAA SPACTELETV MMDWLGKMLE LPKAFLNEKA GEGGGVIQGS ASEATLVALL AARTKVIHRL QAASPELTQA AIMEKLVAYS SDQAHSSVER AGLIGGVKLK AIPSDGNFAM RASALQEALE RDKAAGLIPF FMVATLGTTT CCSFDNLLEV GPICNKEDIW LHVDAAYAGS AFICPEFRHL LNGVEFADSF NFNPHKWLLV NFDCSAMWVK KRTDLTGAFR LDPTYLKHSH QDSGLITDYR HWQIPLGRRF RSLKMWFVFR MYGVKGLQAY IRKHVQLSHE FESLVRQDPR FEICVEVILG LVCFRLKGSN KVNEALLQRI NSAKKIHLVP CHLRDKFVLR FAICSRTVES AHVQRAWEHI KELAADVLRA ERE

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 2mM DTT, 10% glycerol.

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at +2°C to +8°C for 1 week.
For long term storage, aliquot and store at -20°C or -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

56.4 kDa (503aa), confirmed by MALDI-TOF.

OMIM

M76180 mRNA

3D Structure

ModBase 3D Structure for P20711

Antigen Species

Human

Tag

His-tag

Domain

1-480aa

Endotoxin

< 1EU per 1 ug of protein (determined by LAL Method).

Product Categories/Family for DDC recombinant protein

Neuroscience

Applications Tested/Suitable for DDC recombinant protein

SDS-PAGE

Product References and Citations for DDC recombinant protein

Avgeris M., et al. (2008). Clin Biochem. 41 (14-15):1140-9.; Pons R., et al. (2004). Neruology. 62 (7):1058-65.;

Other Notes

Small volumes of DDC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DDC purchase

MBS203181 is a recombinant protein targeting DDC. Also known as Dopa decarboxylase, 1-480aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DDC. It may not necessarily be applicable to this product.

NCBI GI #

132814448

NCBI GeneID

1644

NCBI Accession #

NP_001076440.2

UniProt Primary Accession #

P20711

UniProt Secondary Accession #

Q16723; Q5W5T9; Q75MJ6; C9IYA0; E7ER62; E7EU95

UniProt Related Accession #

P20711

GenBank Nucleotide #

NM_001082971.1

NCBI Official Full Name

aromatic-L-amino-acid decarboxylase isoform 1

NCBI Official Synonym Full Names

dopa decarboxylase

NCBI Official Symbol

DDC

NCBI Official Synonym Symbols

AADC

UniProt Protein Name

Aromatic-L-amino-acid decarboxylase

UniProt Synonym Protein Names

DOPA decarboxylase; DDC

Protein Family

Aromatic-L-amino-acid decarboxylase

UniProt Gene Name

DDC

UniProt Synonym Gene Names

AADC; AADC; DDC

NCBI Protein Information

aromatic-L-amino-acid decarboxylase

NCBI Summary for DDC

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]

UniProt Comments for DDC

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Research Articles on DDC

1. IKZF1 rs10235796 C allele, IKZF1 rs6964969A>G, CDKN2A rs3731246 G>C, and CDKN2A rs3731246 C allele were signi fi cantly associated with Acute Lymphoblastic Leukemia in Yemenis of Arab-Asian descent. Borderline association found in IKZF1 rs4132601 T>G variant. No associations found with IKZF1 rs11978267 or rs7789635, DDC rs3779084; rs880028; rs7809758, CDKN2A rs3731217, CEBPE rs2239633; rs12434881

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DDC recombinant protein

Reference Product	PubMed Publications
DBH recombinant protein	>43 publications with DDC and DBH
COMT recombinant protein	>40 publications with DDC and COMT
TPH2 recombinant protein	>14 publications with DDC and TPH2
MAOA recombinant protein	>13 publications with DDC and MAOA
TPH1 recombinant protein	>11 publications with DDC and TPH1
MAOB recombinant protein	>10 publications with DDC and MAOB
PAH recombinant protein	>6 publications with DDC and PAH
ABP1 recombinant protein	>1 publications with DDC and ABP1

Pathways associated with DDC recombinant protein

Products by Pathway	Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Amine-derived Hormones Pathway antibodies	Amine-derived Hormones Pathway Diagram
Amino Acid Metabolism Pathway antibodies	Amino Acid Metabolism Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Biogenic Amine Synthesis Pathway antibodies	Biogenic Amine Synthesis Pathway Diagram
Catecholamine Biosynthesis Pathway antibodies	Catecholamine Biosynthesis Pathway Diagram
Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies	Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies	Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram

Diseases associated with DDC recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>150 publications with DDC and Disease Models, Animal
Liver Diseases Antibodies	>147 publications with DDC and Liver Diseases
Brain Diseases Antibodies	>116 publications with DDC and Brain Diseases
Movement Disorders Antibodies	>75 publications with DDC and Movement Disorders
Mental Disorders Antibodies	>74 publications with DDC and Mental Disorders
Hepatitis Antibodies	>70 publications with DDC and Hepatitis
Poisoning Antibodies	>70 publications with DDC and Poisoning
Parkinsonian Disorders Antibodies	>67 publications with DDC and Parkinsonian Disorders
Parkinson Disease Antibodies	>57 publications with DDC and Parkinson Disease
Inflammation Antibodies	>56 publications with DDC and Inflammation

Organs/Tissues associated with DDC recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>451 publications with DDC and Blood
Liver Antibodies	>354 publications with DDC and Liver
Brain Antibodies	>309 publications with DDC and Brain
Nerve Antibodies	>83 publications with DDC and Nerve
Kidney Antibodies	>71 publications with DDC and Kidney
Lung Antibodies	>50 publications with DDC and Lung
Eye Antibodies	>43 publications with DDC and Eye
Intestine Antibodies	>32 publications with DDC and Intestine
Prostate Antibodies	>31 publications with DDC and Prostate
Pancreas Antibodies	>24 publications with DDC and Pancreas