Malondialdehyde ELISA Kits

Malondialdhyde is a naturally occurring highly reactive organic compound that is used extensively as an biomarker for oxidative stress. An increase in free radicals generated during lipid oxidation process in an organism gives rise to a number of secondary products such as MDA, propanol, and hexanal. Malondialdehyde is one of the principal products of lipid peroxidation produced by cells when there is excess free radicals. Malondialdehyde level is commonly known as a marker of oxidative stress and the antioxidant status in cancerous patients. Malondialdehyde is a highly toxic molecule and should be considered as more than just a marker of lipid peroxidation. Malondialdehyde-derived adducts on proteins have been implicated in cardiovascular diseases, neurodegenerative disorders, and other clinical conditions. Its interaction with DNA and proteins has often been referred to as potentially mutagenic and atherogenic.

MDA can be generated in vivo by decomposition of arachidonic acid (AA) and larger polu unsaturafed fatty acids as a side product by enzymatic processes during the biosynthesis of thromboxane A2 (TXA2) or through nonenzymatic processes by bicyclic endoperoxides produced during lipid peroxidation. Once formed MDA can be enzymatically metabolized or can react on cellular proteins or DNA to form adducts resulting in biomolecular damages. Various experiments provide biological and biochemical evidence for the existence of MDA-induced DNA interstrand cross-links that could result from endogenous oxidative stress and likely have potent biological effects.