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Opticin (OPTC) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602018

Opticin (oculoglycan) is a member of the small leucine-rich proteoglycan (SLRP) family with homology to class III extracellular matrix family members epiphycan and mimecan. It forms a 90kD non-covalent dimer that is a component of vitreous collagen fibrils in… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Opticin (OPTC), Monoclonal Antibody
Full Product Name
Opticin (Oculoglycan)
Product Gene Name
Product Synonym Names
Anti -Opticin (Oculoglycan)
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
7H137
Host
Rat
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
Purity/Purification
Purified by Protein G affinity chromatography from hybridoma culture supernatant.
Concentration
~0.5 mg/mL (after reconstitution) (lot specific)
Specificity
Recognizes human Opticin at ~90kD. No cross-reactivity with recombinant mouse Opticin.
Preparation and Storage
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Chromosome Location
chromosome: 1; Location: 1q32.1
OMIM
605127
3D Structure
ModBase 3D Structure for Q9UBM4
Immunogen
Recombinant protein corresponding to Ala20-Thr332 from human Opticin, expressed in NS0 cells.

Product Categories/Family for anti-OPTC antibody

Applications Tested/Suitable for anti-OPTC antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-OPTC antibody
Western Blot: 1ug/mL, Recombinant human Opticin. Optimal dilutions to be determined by the researcher. Other applications have not been tested.

Other Notes

Small volumes of anti-OPTC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OPTC purchase

MBS602018 is an antibody targeting OPTC. Also known as Opticin (Oculoglycan). Reactive in Human. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for OPTC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
opticin
NCBI Official Synonym Full Names
opticin
NCBI Official Symbol
OPTC
NCBI Official Synonym Symbols
OPT; OPTC
UniProt Protein Name
Opticin
UniProt Synonym Protein Names
Oculoglycan
Protein Family
UniProt Gene Name
OPTC
UniProt Synonym Gene Names
OPT
UniProt Entry Name
OPT_HUMAN
NCBI Protein Information
opticin; oculoglycan

NCBI Summary for OPTC

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq]
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UniProt Comments for OPTC

OPTC: Binds collagen fibrils. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: proteinaceous extracellular matrix

Molecular Function: extracellular matrix structural constituent

Biological Process: negative regulation of angiogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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