Human NUCB2 Active Protein – Cat# MBS691633

Nesfatin (NUCB2) Human Active Protein

Name: NUCB2 Active Protein; Nesfatin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691633
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691633

Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Originally identified as a hypothalamic neuropeptide, Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic… More details

$305 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nesfatin (NUCB2), Active Protein

Full Product Name

Human Nesfatin

Product Gene Name

NUCB2 active protein

Product Synonym Names

Nesfatin

Sequence

VPIDIDKTKV QNIHPVESAK IEPPDTGLYY DEYLKQVIDV LETDKH FREK LQKADIEEIK SGRLSKELDL VSHHVRTKLD EL

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

>98% (SDS-PAGE, HPLC)

Molecular Weight

50,196 Da

Chromosome Location

Chromosome: 11; NC_000011.10 (17260337..17349963). Location: 11p15.1

OMIM

608020

3D Structure

ModBase 3D Structure for P80303

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by an in vivo assay using healthy wild type male mice (C57BL/6J). Mice were treated via intraperitoneal injection once at a dose of 4 ug Nesfatin-1/gm of body weight. Significant effects on body weight and food consumption were observed relative to saline-treated controls.

Product Categories/Family for NUCB2 active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of NUCB2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NUCB2 purchase

MBS691633 is an active protein targeting NUCB2. Also known as Human Nesfatin. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NUCB2. It may not necessarily be applicable to this product.

NCBI GI #

4826870

NCBI GeneID

4925

NCBI Accession #

NP_005004.1

UniProt Primary Accession #

P80303

UniProt Secondary Accession #

Q8NFT5; A8K642; D3DQX5

UniProt Related Accession #

P80303

GenBank Nucleotide #

NM_005013.2

NCBI Official Full Name

nucleobindin-2

NCBI Official Synonym Full Names

nucleobindin 2

NCBI Official Symbol

NUCB2

NCBI Official Synonym Symbols

NEFA; HEL-S-109

UniProt Protein Name

Nucleobindin-2

UniProt Synonym Protein Names

DNA-binding protein NEFA; Gastric cancer antigen Zg4; Prepronesfatin

Protein Family

Nucleobindin

UniProt Gene Name

NUCB2

UniProt Synonym Gene Names

NEFA

UniProt Entry Name

NUCB2_HUMAN

NCBI Protein Information

nucleobindin-2; nesfatin-1; prepronefastin; prepronesfatin; nucleobinding 2; DNA-binding protein NEFA; gastric cancer antigen Zg4; epididymis secretory protein Li 109

NCBI Summary for NUCB2

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

UniProt Comments for NUCB2

Function: Calcium-binding protein. May have a role in calcium homeostasis.Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance

By similarity.

Subcellular location: Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted Ref.8. Endoplasmic reticulum

By similarity. Nucleus envelope

By similarity. Note: Golgi retention is mediated by its N-terminal region. Ref.8Nesfatin-1: Secreted Ref.8.

Tissue specificity: Predominantly expressed in spleen, testis and normal stomach. Ref.3

Polymorphism: Deletion of Gln-402 is frequent.

Miscellaneous: NEFA stands for N=DNA-binding; EF=EF-hand; A=Acidic region.

Sequence similarities: Belongs to the nucleobindin family.Contains 2 EF-hand domains.

Research Articles on NUCB2

1. This study provides a novel regulatory signaling pathway of nesfatin-1-regulated ovarian epithelial carcinoma growth and may contribute to ovarian cancer prevention and therapy, especially in obese patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NUCB2 active protein

Reference Product	PubMed Publications
POMC active protein	>9 publications with NUCB2 and POMC
ERAP1 active protein	>2 publications with NUCB2 and ERAP1

Diseases associated with NUCB2 active protein

Disease Name	Pubmed Publications
Weight Gain Antibodies	>10 publications with NUCB2 and Weight Gain
Disease Models, Animal Antibodies	>4 publications with NUCB2 and Disease Models, Animal
Neoplasms Antibodies	>4 publications with NUCB2 and Neoplasms
Liver Diseases Antibodies	>3 publications with NUCB2 and Liver Diseases
Necrosis Antibodies	>3 publications with NUCB2 and Necrosis
Inflammation Antibodies	>3 publications with NUCB2 and Inflammation
Carcinoma Antibodies	>2 publications with NUCB2 and Carcinoma
Weight Loss Antibodies	>1 publications with NUCB2 and Weight Loss
Fibrosis Antibodies	>1 publications with NUCB2 and Fibrosis
Kidney Diseases Antibodies	>1 publications with NUCB2 and Kidney Diseases

Organs/Tissues associated with NUCB2 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>51 publications with NUCB2 and Brain
Blood Antibodies	>18 publications with NUCB2 and Blood
Stomach Antibodies	>17 publications with NUCB2 and Stomach
Pancreas Antibodies	>14 publications with NUCB2 and Pancreas
Liver Antibodies	>9 publications with NUCB2 and Liver
Adipose Tissue Antibodies	>8 publications with NUCB2 and Adipose Tissue
Intestine Antibodies	>5 publications with NUCB2 and Intestine
Pituitary Gland Antibodies	>4 publications with NUCB2 and Pituitary Gland
Heart Antibodies	>4 publications with NUCB2 and Heart
Ovary Antibodies	>4 publications with NUCB2 and Ovary