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Complement C4 (C4B) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626457

C4 consists of three polypeptide chains (alpha, molecular weight 95kD, beta, molecular weight 75kD and gamma, molecular weight 33kD) and is usually present in serum at 200-600mg/L. It is a protein of the classical complement pathway. When activated by C1s, a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Complement C4 (C4b), Polyclonal Antibody
Full Product Name
Complement C4, Human
Product Gene Name
Product Synonym Names
Anti -Complement C4, Human
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in TBS, pH 7.5, 0.1% sodium azide
Purity/Purification
Serum
Specificity
Recognizes human complement component C4 (pooled normal human plasma and pooled 2X concentrated human serum) by immunoelectrophoresis
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 20; NC_005119.2 (4106123..4145904). Location: 20p12
3D Structure
ModBase 3D Structure for P08649
Immunogen
Purified human C4 protein

Product Categories/Family for anti-C4b antibody

Application Notes for anti-C4b antibody
Suitable for use in ELISA. Other applications not tested

Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of anti-C4b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C4b purchase

MBS626457 is an antibody targeting C4b. Also known as Complement C4, Human. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for C4b. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
complement C4
NCBI Official Synonym Full Names
complement component 4B (Chido blood group)
NCBI Official Symbol
C4b
NCBI Official Synonym Symbols
C4; C4a; C4-1
UniProt Protein Name
Complement C4
Protein Family
UniProt Gene Name
C4
UniProt Synonym Gene Names
C4a
UniProt Entry Name
CO4_RAT
NCBI Protein Information
complement C4; complement component 4a; complement component 4, gene 1; complement component 4 (within H-2S); complement component 4B (Childo blood group)

NCBI Summary for C4b

complement protein, part of the classical activation pathway; localizes to the class III region of the MHC [RGD]

UniProt Comments for C4b

C4A: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function: complement component C1q binding; endopeptidase inhibitor activity

Biological Process: innate immune response; inflammatory response; complement activation, classical pathway; complement activation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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