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C Reactive Protein (CRP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003263
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MBS2003263 is an antibody targeting CRP. Also known as Polyclonal Antibody to C Reactive Protein (CRP). Reactive in Homo sapiens (Human). Host: Rabbit. More details

$180 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C Reactive Protein (CRP), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to C Reactive Protein (CRP)
Product Gene Name
anti-CRP antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Homo sapiens (Human)
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at 4 degree C for 12 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: CRP (MBS2003263)
Biotin Conjugated Antibody: CRP (MBS2007227)
Matching Pairs
Unconjugated Antibody: CRP (MBS2003263)
Immunogen: CRP (MBS2009191)
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OMIM
M11880 Genomic DNA
3D Structure
ModBase 3D Structure for P02741
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Cross Reactivity
Mouse;Rat
Immunogen
Recombinant CRP (Phe17~Pro224) expressed in E.coli (MBS2009191)
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CRP antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-CRP antibody
Western blotting: 0.01-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunofluorescence: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Immunohistochemistry (IHC) of anti-CRP antibody

DAB staining on IHC-P; Samples: Human Liver Tissue; Primary Ab: 20ug/ml Rabbit Anti-Human CRP Antibody Second Ab: 2ug/mL HRP- Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-CRP Polyclonal Antibody – Cat# MBS2003263

Immunohistochemistry (IHC) of anti-CRP antibody

DAB staining on IHC-P; Samples: Human Liver cancer Tissue; Primary Ab: 20ug/ml Rabbit Anti-Human CRP Antibody Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-CRP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003263

Immunohistochemistry (IHC) of anti-CRP antibody

DAB staining on IHC-P; Samples: Human Kidney Tissue; Primary Ab: 20ug/ml Rabbit Anti-Human CRP Antibody Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-CRP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003263

Immunohistochemistry (IHC) of anti-CRP antibody

DAB staining on IHC-P; Samples: Human Breast cancer Tissue; Primary Ab: 20ug/ml Rabbit Anti-Human CRP Antibody Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-CRP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003263

Western Blot (WB) of anti-CRP antibody

Western Blot: Sample: Lane1: Rat Serum; Lane2: Mouse Serum.
Rabbit Anti-CRP Polyclonal Antibody, Western Blot (WB) – Cat# MBS2003263

Immunohistochemistry (IHC) of anti-CRP antibody

DAB staining on IHC-P;
Samples: Human Rectum Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Human CRP Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047 ).
Rabbit Anti-CRP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003263

Immunohistochemistry (IHC) of anti-CRP antibody

DAB staining on IHC-P
Sample: Mouse Liver Tissue
Primary Ab: 20ug/ml Rabbit Anti-Human CRP Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-CRP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003263

Immunofluorescence (IF) of anti-CRP antibody

AF488 staining on IF
Sample: Hela cell
Primary Ab: 20ug/ml Rabbit Anti-Human Rat Serum;CRP Antibody
Second Ab: 2ug/ml AF488-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-CRP Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2003263

Other Notes

Small volumes of anti-CRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CRP. It may not necessarily be applicable to this product.

NCBI GI #
55770842
NCBI GeneID
1401
NCBI Accession #
NP_000558.2
UniProt Primary Accession #
P02741
UniProt Secondary Accession #
Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0
UniProt Related Accession #
P02741
GenBank Nucleotide #
NM_000567.2
NCBI Official Full Name
C-reactive protein isoform 1
NCBI Official Synonym Full Names
C-reactive protein
NCBI Official Symbol
CRP
NCBI Official Synonym Symbols
PTX1
UniProt Protein Name
C-reactive protein
Protein Family
C-reactive protein
UniProt Gene Name
CRP
UniProt Synonym Gene Names
PTX1
NCBI Protein Information
C-reactive protein

NCBI Summary for CRP

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
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UniProt Comments for CRP

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular region; extracellular space

Molecular Function: calcium ion binding; choline binding; complement component C1q binding; low-density lipoprotein particle binding; low-density lipoprotein receptor binding; protein binding; virion binding

Biological Process: acute-phase response; defense response to Gram-positive bacterium; inflammatory response; opsonization; positive regulation of superoxide anion generation
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Research Articles on CRP

1. Data show that the inflammation of the gallbladder wall (IGW) correlated significantly with plasma GPX1 and hs-CRP (high-sensitivity C-reactive protein) values suggesting that inflammation and oxidative stress are related.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRP antibody

 Reference Product  PubMed Publications
 ICAM1 antibody  >427 publications with CRP and ICAM1
 IL6 antibody  >354 publications with CRP and IL6
 SERPINE1 antibody  >277 publications with CRP and SERPINE1
 STAT3 antibody  >34 publications with CRP and STAT3
 CFH antibody  >20 publications with CRP and CFH
 FCGR2A antibody  >7 publications with CRP and FCGR2A
 LEP antibody  >5 publications with CRP and LEP

Pathways associated with anti-CRP antibody

 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram

Diseases associated with anti-CRP antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9649 publications with CRP and Inflammation
 Cardiovascular Diseases Antibodies  >7370 publications with CRP and Cardiovascular Diseases
 Infection Antibodies  >3913 publications with CRP and Infection
 Heart Diseases Antibodies  >3551 publications with CRP and Heart Diseases
 Metabolic Diseases Antibodies  >3221 publications with CRP and Metabolic Diseases
 Myocardial Ischemia Antibodies  >2877 publications with CRP and Myocardial Ischemia
 Necrosis Antibodies  >2687 publications with CRP and Necrosis
 Atherosclerosis Antibodies  >2516 publications with CRP and Atherosclerosis
 Arthritis, Rheumatoid Antibodies  >1769 publications with CRP and Arthritis, Rheumatoid
 Pain Antibodies  >1720 publications with CRP and Pain

Organs/Tissues associated with anti-CRP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16698 publications with CRP and Blood
 Liver Antibodies  >1184 publications with CRP and Liver
 Muscle Antibodies  >1022 publications with CRP and Muscle
 Lung Antibodies  >928 publications with CRP and Lung
 Brain Antibodies  >891 publications with CRP and Brain
 Pancreas Antibodies  >126 publications with CRP and Pancreas
 Bladder Antibodies  >54 publications with CRP and Bladder
 Placenta Antibodies  >53 publications with CRP and Placenta
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