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CD27 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS127294
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD27, Polyclonal Antibody
Full Product Name
CD27 Polyclonal Antibody
Product Gene Name
anti-CD27 antibody
Product Synonym Names
MGC20393; S152; T14; TNFRSF7; Tp55
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
260
OMIM
gene 615122
3D Structure
ModBase 3D Structure for P26842
Species
Human
Immunogen
Recombinant protein of human CD27
Calculated Molecular Weight
50kDa

Product Categories/Family for anti-CD27 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD27 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CD27 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Western Blot (WB) of anti-CD27 antibody

Western blot analysis of extracts of various cell lines, using CD27 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-CD27 Polyclonal Antibody – Cat# MBS127294

Other Notes

Small volumes of anti-CD27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD27 purchase

MBS127294 is an antibody targeting CD27. Also known as CD27 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD27. It may not necessarily be applicable to this product.

NCBI GI #
269849546
NCBI GeneID
939
NCBI Accession #
P26842.2
UniProt Primary Accession #
P26842
UniProt Secondary Accession #
B2RDZ0
UniProt Related Accession #
P26842
NCBI Official Full Name
CD27 antigen
NCBI Official Synonym Full Names
CD27 molecule
NCBI Official Symbol
CD27
NCBI Official Synonym Symbols
T14; S152; Tp55; TNFRSF7; S152. LPFS2
UniProt Protein Name
CD27 antigen
UniProt Synonym Protein Names
CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27
Protein Family
CD27 antigen
UniProt Gene Name
CD27
UniProt Synonym Gene Names
TNFRSF7
UniProt Entry Name
CD27_HUMAN
NCBI Protein Information
CD27 antigen; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7

UniProt Comments for CD27

CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Protein type: Receptor, cytokine; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; caspase inhibitor activity

Biological Process: release of cytoplasmic sequestered NF-kappaB; response to ethanol; cell surface receptor linked signal transduction; positive regulation of B cell differentiation; positive regulation of JNK cascade; immunoglobulin mediated immune response; negative regulation of caspase activity; negative regulation of apoptosis

Disease: Lymphoproliferative Syndrome 2
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Research Articles on CD27

1. A lower primary CD24(hi) CD27(+) CD19(+) B cells may be an immunologic aspect of new-onset SLE that may be a useful tool to evaluate lupus activity and monitor the response to therapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD27 antibody

 Reference Product  PubMed Publications
 CD70 antibody  >255 publications with CD27 and CD70
 CD38 antibody  >245 publications with CD27 and CD38
 CCR7 antibody  >209 publications with CD27 and CCR7
 CD5 antibody  >117 publications with CD27 and CD5
 CXCR3 antibody  >48 publications with CD27 and CXCR3
 TRAF2 antibody  >13 publications with CD27 and TRAF2
 SIVA1 antibody  >12 publications with CD27 and SIVA1
 TRAF3 antibody  >8 publications with CD27 and TRAF3
 CCR3 antibody  >5 publications with CD27 and CCR3
 CD40LG antibody  >1 publications with CD27 and CD40LG

Pathways associated with anti-CD27 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-CD27 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >891 publications with CD27 and Immune System Diseases
 Necrosis Antibodies  >426 publications with CD27 and Necrosis
 Lymphoma Antibodies  >224 publications with CD27 and Lymphoma
 Inflammation Antibodies  >166 publications with CD27 and Inflammation
 Nervous System Diseases Antibodies  >100 publications with CD27 and Nervous System Diseases
 Skin Diseases Antibodies  >91 publications with CD27 and Skin Diseases
 Neoplasms, Experimental Antibodies  >80 publications with CD27 and Neoplasms, Experimental
 Liver Diseases Antibodies  >63 publications with CD27 and Liver Diseases
 Carcinoma Antibodies  >59 publications with CD27 and Carcinoma
 Memory Disorders Antibodies  >43 publications with CD27 and Memory Disorders

Organs/Tissues associated with anti-CD27 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2318 publications with CD27 and Blood
 Lymph Node Antibodies  >172 publications with CD27 and Lymph Node
 Spleen Antibodies  >150 publications with CD27 and Spleen
 Lymph Antibodies  >140 publications with CD27 and Lymph
 Lung Antibodies  >88 publications with CD27 and Lung
 Kidney Antibodies  >82 publications with CD27 and Kidney
 Thymus Antibodies  >78 publications with CD27 and Thymus
 Tonsil Antibodies  >61 publications with CD27 and Tonsil
 Intestine Antibodies  >38 publications with CD27 and Intestine
 Heart Antibodies  >36 publications with CD27 and Heart
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