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Keratin 17 (KRT17) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2004582
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MBS2004582 is an antibody targeting KRT17. Also known as Polyclonal Antibody to Keratin 17 (KRT17). Reactive in Human, Mouse, Rat, Pig. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Keratin 17 (KRT17), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Keratin 17 (KRT17)
Product Gene Name
anti-KRT17 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF-ILNEMRD QY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Pig
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
1mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against KRT17. It has been selected for its ability to recognize KRT17 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: KRT17 (MBS2004582)
Biotin Conjugated Antibody: KRT17 (MBS2007230)
Matching Pairs
Unconjugated Antibody: KRT17 (MBS2004582)
Immunogen: KRT17 (MBS2009798)
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Molecular Weight
48,106 Da
OMIM
Z19574 Genomic DNA
3D Structure
ModBase 3D Structure for Q04695
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant KRT17 (Ile252~Ala393) expressed in E.coli.
Cross Reactivity
Human, Rat, Pig
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2059542
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-KRT17 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-KRT17 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-KRT17 antibody

Western Blot: Sample: Porcine Skin lysate; Primary Ab: 1ug/ml Rabbit Anti-Human KRT17 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-KRT17 Polyclonal Antibody – Cat# MBS2004582

Western Blot (WB) of anti-KRT17 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-KRT17 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2004582

Immunohistochemistry (IHC) of anti-KRT17 antibody

DAB staining on fromalin fixed paraffin- embedded kidney tissue)
Rabbit Anti-KRT17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2004582

Immunohistochemistry (IHC) of anti-KRT17 antibody

DAB staining on IHC-P; Samples: Human Kidney Tissue)
Rabbit Anti-KRT17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2004582

Other Notes

Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.

NCBI GI #
4557701
NCBI GeneID
3872
NCBI Accession #
NP_000413.1
UniProt Primary Accession #
Q04695
UniProt Secondary Accession #
Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2
UniProt Related Accession #
Q04695
GenBank Nucleotide #
NM_000422.2
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17
NCBI Official Synonym Symbols
PC; K17; PC2; 39.1; CK-17; PCHC1
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17; K17
Protein Family
Keratin
UniProt Gene Name
KRT17
UniProt Synonym Gene Names
CK-17; K17
NCBI Protein Information
keratin, type I cytoskeletal 17

NCBI Summary for KRT17

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

UniProt Comments for KRT17

K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cell periphery; cytosol; extracellular exosome; intermediate filament; intermediate filament cytoskeleton

Molecular Function: MHC class II protein binding; MHC class II receptor activity; protein binding; structural constituent of cytoskeleton

Biological Process: cornification; epidermis development; hair follicle morphogenesis; intermediate filament organization; keratinization; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation; signal transduction

Disease: Pachyonychia Congenita 2; Steatocystoma Multiplex
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Research Articles on KRT17

1. Krt17 was demonstrated to contribute to areca nut-induced oral malignancy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KRT17 antibody

 Reference Product  PubMed Publications
 KRT6A antibody  >17 publications with KRT17 and KRT6A
 KRT7 antibody  >1 publications with KRT17 and KRT7

Pathways associated with anti-KRT17 antibody

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with anti-KRT17 antibody

 Disease Name  Pubmed Publications
 Pachyonychia congenita Jackson Lawler type Antibodies  >20 publications with KRT17 and Pachyonychia congenita Jackson Lawler type
 Neoplasms Antibodies  >19 publications with KRT17 and Neoplasms
 Adenocarcinoma Antibodies  >7 publications with KRT17 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >7 publications with KRT17 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >5 publications with KRT17 and Breast Neoplasms
 Pain Antibodies  >4 publications with KRT17 and Pain
 Skin Neoplasms Antibodies  >3 publications with KRT17 and Skin Neoplasms
 Carcinoma, Basal Cell Antibodies  >2 publications with KRT17 and Carcinoma, Basal Cell
 Esophageal Squamous Cell Carcinoma Antibodies  >2 publications with KRT17 and Esophageal Squamous Cell Carcinoma
 Precancerous Conditions Antibodies  >1 publications with KRT17 and Precancerous Conditions

Organs/Tissues associated with anti-KRT17 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >16 publications with KRT17 and Skin
 Mouth Antibodies  >3 publications with KRT17 and Mouth
 Lymph Antibodies  >2 publications with KRT17 and Lymph
 Mammary Gland Antibodies  >2 publications with KRT17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with KRT17 and Lymph Node
 Intestine Antibodies  >1 publications with KRT17 and Intestine
 Bladder Antibodies  >1 publications with KRT17 and Bladder
 Prostate Antibodies  >1 publications with KRT17 and Prostate
 Muscle Antibodies  >1 publications with KRT17 and Muscle
 Pancreas Antibodies  >1 publications with KRT17 and Pancreas
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