CLAP2 Antibody – Rabbit Polyclonal

CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: kinetochore microtubule; Golgi apparatus; microtubule; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; microtubule organizing center; cell cortex; trans-Golgi network; cytosol

Molecular Function: microtubule plus-end binding; protein binding; galactoside 2-alpha-L-fucosyltransferase activity

Biological Process: mitosis; microtubule organizing center organization and biogenesis; axon guidance; regulation of microtubule-based process; cell division; negative regulation of microtubule depolymerization; establishment and/or maintenance of cell polarity; mitotic cell cycle; microtubule nucleation; regulation of microtubule polymerization or depolymerization