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FLT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS125301
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This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a… More details

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Product Overview

Online Datasheet in PDF
Product Name
FLT1, Polyclonal Antibody
Full Product Name
FLT1 Polyclonal Antibody
Product Gene Name
anti-FLT1 antibody
Product Synonym Names
VEGF Receptor 1: FLT; FLT-1; VEGFR1; VEGFR-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
Molecular Weight
Observed MW: 200kDa
Calculated MW: 151kDa
OMIM
165070
3D Structure
ModBase 3D Structure for P17948
Cross-Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein (or fragment).

Product Categories/Family for anti-FLT1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FLT1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-FLT1 antibody
WB: 1:500 - 1:1000
IF/ICC: 1:50 - 1:200
ELISA: Recommended starting concentration is 1 ug/mL. Please optimize the concentration based on your specific assay requirements.

Western Blot (WB) of anti-FLT1 antibody

Western blot analysis of extracts of LO2 cells, using FLT1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
Rabbit Anti-FLT1 Polyclonal Antibody – Cat# MBS125301

Western Blot (WB) of anti-FLT1 antibody

Western blot analysis of various lysates using VEGFR1 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 180s
Rabbit Anti-FLT1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS125301

Immunofluorescence (IF) of anti-FLT1 antibody

Immunofluorescence analysis of NIH/3T3 cells using VEGFR1 Rabbit pAb at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-FLT1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS125301

Immunofluorescence (IF) of anti-FLT1 antibody

Immunofluorescence analysis of U2OS cells using VEGFR1 Rabbit pAb at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-FLT1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS125301

Other Notes

Small volumes of anti-FLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FLT1 purchase

MBS125301 is an antibody targeting FLT1. Also known as FLT1 Polyclonal Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FLT1. It may not necessarily be applicable to this product.

NCBI GI #
143811474
NCBI GeneID
2321
NCBI Accession #
P17948.2
UniProt Primary Accession #
P17948
UniProt Secondary Accession #
O60722; A3E342; A3E344; A8KA71; B0LPF1; B2BF46; B2BF47; B2BF48; B3FR89; B5A923; F5H5L6
UniProt Related Accession #
P17948
NCBI Official Full Name
Vascular endothelial growth factor receptor 1
NCBI Official Synonym Full Names
fms-related tyrosine kinase 1
NCBI Official Symbol
FLT1
NCBI Official Synonym Symbols
FLT; FLT-1; VEGFR1; VEGFR-1
UniProt Protein Name
Vascular endothelial growth factor receptor 1
UniProt Synonym Protein Names
Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor
Protein Family
Vascular endothelial growth factor receptor
UniProt Gene Name
FLT1
UniProt Synonym Gene Names
FLT; FRT; VEGFR1; VEGFR-1; FLT-1; FLT
UniProt Entry Name
VGFR1_HUMAN
NCBI Protein Information
vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

UniProt Comments for FLT1

VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; EC 2.7.10.1; Protein kinase, TK; TK group; VEGFR family

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: extracellular space; focal adhesion; integral to plasma membrane; plasma membrane; endosome; receptor complex

Molecular Function: identical protein binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; patterning of blood vessels; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; blood vessel morphogenesis; embryonic morphogenesis; sprouting angiogenesis; cell differentiation; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
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Research Articles on FLT1

1. Data indicate that FLT1 receptor tyrosine kinase was overexpressed in primary colorectal carcinoma (CRC) and their nodal metastases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FLT1 antibody

 Reference Product  PubMed Publications
 VEGFA antibody  >167 publications with FLT1 and VEGFA
 HIF1A antibody  >38 publications with FLT1 and HIF1A
 PGF antibody  >20 publications with FLT1 and PGF
 VEGFC antibody  >15 publications with FLT1 and VEGFC
 VEGFB antibody  >10 publications with FLT1 and VEGFB
 NRP1 antibody  >8 publications with FLT1 and NRP1
 EPAS1 antibody  >5 publications with FLT1 and EPAS1
 FIGF antibody  >4 publications with FLT1 and FIGF

Pathways associated with anti-FLT1 antibody

 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram

Diseases associated with anti-FLT1 antibody

 Disease Name  Pubmed Publications
 Pre-Eclampsia Antibodies  >309 publications with FLT1 and Pre-Eclampsia
 Hypertension Antibodies  >130 publications with FLT1 and Hypertension
 Disease Models, Animal Antibodies  >120 publications with FLT1 and Disease Models, Animal
 Proteinuria Antibodies  >69 publications with FLT1 and Proteinuria
 Inflammation Antibodies  >53 publications with FLT1 and Inflammation
 Nervous System Diseases Antibodies  >51 publications with FLT1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >40 publications with FLT1 and Adenocarcinoma
 Kidney Diseases Antibodies  >37 publications with FLT1 and Kidney Diseases
 Brain Diseases Antibodies  >37 publications with FLT1 and Brain Diseases
 Heart Diseases Antibodies  >37 publications with FLT1 and Heart Diseases

Organs/Tissues associated with anti-FLT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1052 publications with FLT1 and Vascular
 Blood Antibodies  >617 publications with FLT1 and Blood
 Placenta Antibodies  >350 publications with FLT1 and Placenta
 Embryonic Tissue Antibodies  >127 publications with FLT1 and Embryonic Tissue
 Muscle Antibodies  >88 publications with FLT1 and Muscle
 Bone Antibodies  >81 publications with FLT1 and Bone
 Liver Antibodies  >74 publications with FLT1 and Liver
 Kidney Antibodies  >73 publications with FLT1 and Kidney
 Lung Antibodies  >68 publications with FLT1 and Lung
 Heart Antibodies  >61 publications with FLT1 and Heart
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