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NMNAT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9133850
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This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus,… More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NMNAT2, Polyclonal Antibody
Full Product Name
NMNAT2 Polyclonal Antibody
Product Gene Name
anti-NMNAT2 antibody
Product Synonym Names
NMNAT2; C1orf15; PNAT2; nicotinamide nucleotid e adenylyltransferase 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
PBS with 0.05% proclin300, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Molecular Weight
34 kDa
OMIM
AF288395 mRNA
3D Structure
ModBase 3D Structure for Q9BZQ4
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human NMNAT2 (NP_733820.1).
Cross/Species Reactivity
Human, Mouse, Rat

Product Categories/Family for anti-NMNAT2 antibody

Polyclonal Antibodies
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NMNAT2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-NMNAT2 antibody
WB: 1:200 - 1:500

Western Blot (WB) of anti-NMNAT2 antibody

Western blot analysis of extracts of various cell lines, using NMNAT2 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
Rabbit Anti-NMNAT2 Polyclonal Antibody – Cat# MBS9133850

Western Blot (WB) of anti-NMNAT2 antibody

Western blot analysis of various lysates, using NMNAT2 antibody (MBS9133850) at 1:400 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 180s
Rabbit Anti-NMNAT2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9133850

Other Notes

Small volumes of anti-NMNAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NMNAT2 purchase

MBS9133850 is an antibody targeting NMNAT2. Also known as NMNAT2 Polyclonal Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NMNAT2. It may not necessarily be applicable to this product.

NCBI GI #
24307989
NCBI GeneID
23057
NCBI Accession #
NP_055854.1
UniProt Primary Accession #
Q9BZQ4
UniProt Secondary Accession #
O75067; Q5T1Q3; Q8WU99; Q96QW1
UniProt Related Accession #
Q9BZQ4
GenBank Nucleotide #
NM_015039.3
NCBI Official Full Name
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 1
NCBI Official Synonym Full Names
nicotinamide nucleotide adenylyltransferase 2
NCBI Official Symbol
NMNAT2
NCBI Official Synonym Symbols
PNAT2; C1orf15
UniProt Protein Name
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
UniProt Synonym Protein Names
Nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NaMN adenylyltransferase 2
UniProt Gene Name
NMNAT2
UniProt Synonym Gene Names
C1orf15; KIAA0479; NMN/NaMN adenylyltransferase 2; NMN adenylyltransferase 2; NaMN adenylyltransferase 2
NCBI Protein Information
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

UniProt Comments for NMNAT2

Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity prefers NAD+, NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+.
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Research Articles on NMNAT2

1. Data indicate a chaperone function of nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2), independent from its enzymatic activity, and NMNAT2 complexes with heat shock protein 90 (HSP90) to refold aggregated protein substrates.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NMNAT2 antibody

 Products by Pathway  Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram

Diseases associated with anti-NMNAT2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with NMNAT2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with NMNAT2 and Disease Models, Animal
 Hypertrophy Antibodies  >1 publications with NMNAT2 and Hypertrophy
 Cardiovascular Diseases Antibodies  >1 publications with NMNAT2 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >1 publications with NMNAT2 and Lung Neoplasms

Organs/Tissues associated with anti-NMNAT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with NMNAT2 and Brain
 Embryonic Tissue Antibodies  >4 publications with NMNAT2 and Embryonic Tissue
 Muscle Antibodies  >3 publications with NMNAT2 and Muscle
 Eye Antibodies  >1 publications with NMNAT2 and Eye
 Blood Antibodies  >1 publications with NMNAT2 and Blood
 Heart Antibodies  >1 publications with NMNAT2 and Heart
 Lung Antibodies  >1 publications with NMNAT2 and Lung
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