Integrin Beta1 (ITGB1) Antibody – Rabbit Polyclonal

Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).The beta1 subfamily includes 12 distinct intergrin proteins that bind to different extracellular matrix molecules (4). Control of extracellular integrin binding influences cell adhesion and migration, while intracellular signaling messages relayed by the beta1 cytoplasmic tail helps to regulate cell proliferation, cytoskeletal reorganization and gene expression (4). beta1 integrin is implicated in various activities including embryonic development, blood vessel, skin, bone and muscle formation, as well as tumor metastasis and angiogenesis (4,5).

1. Liu, S. et al. (2000) J. Cell Sci. 113, 3563-3571.
2. Hood, J.D. and Cheresh, D.A. (2002) Nat. Rev. Cancer 2, 91-100.
3. van der Flier, A. and Sonnenberg, A. (2001) Cell Tissue Res. 305, 285-298.
4. Brakebusch, C. and Fässler, R. (2005) Cancer Metastasis Rev. 24, 403-411.
5. Mettouchi, A. and Meneguzzi, G. (2006) Eur. J. Cell Biol. 85, 243-247.

Small volumes of anti-ITGB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125456 is an antibody targeting ITGB1. Also known as Rabbit polyclonal to Integrin beta1. Reactive in Human. Host: Rabbit.