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Integrin Beta 5 (ITGb5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2026529
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MBS2026529 is an antibody targeting ITGb5. Also known as Polyclonal Antibody to Integrin Beta 5 (ITGb5). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Integrin Beta 5 (ITGb5), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Integrin Beta 5 (ITGb5)
Product Gene Name
anti-ITGb5 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-PVD L YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC HLNEANEYTA SNQMDYPSLA LLGEKLAENN
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against ITGb5. It has beenselected for its ability to recognize ITGb5 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: ITGb5 (MBS2026529)
Immunogen: ITGb5 (MBS2029180)
Matching Pairs
Unconjugated Antibody: ITGb5 (MBS2026529)
APC-CY7 Conjugated Antibody: ITGb5 (MBS2063017)
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Molecular Weight
88,054 Da
OMIM
X53002 mRNA
3D Structure
ModBase 3D Structure for P18084
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Fragment
ITGb5 (Pro137~Ile378)
Organism Species
Homo sapiens (Human)
Cross Reactivity
Human, Mouse
Conjugate
No Conjugate
Immunogen
Recombinant ITGb5 (Pro137~Ile378) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2063019
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ITGb5 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-ITGb5 antibody
Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-ITGb5 antibody

Western Blot: Sample: Mouse Heart Tissue.
Rabbit Anti-ITGb5 Polyclonal Antibody – Cat# MBS2026529

Western Blot (WB) of anti-ITGb5 antibody

Western Blot: Sample: Recombinant ITGb5, Human.
Rabbit Anti-ITGb5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2026529

Immunohistochemistry (IHC) of anti-ITGb5 antibody

DAB staining on IHC-P; Samples: Human Liver Cancer Tissue.
Rabbit Anti-ITGb5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2026529

Immunohistochemistry (IHC) of anti-ITGb5 antibody

DAB staining on IHC-P; Samples: Human Prostate Gland Cancer Tissue
Rabbit Anti-ITGb5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2026529

Immunohistochemistry (IHC) of anti-ITGb5 antibody

DAB staining on IHC-P; Samples: Human Glioma Tissue.
Rabbit Anti-ITGb5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2026529

Other Notes

Small volumes of anti-ITGb5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGb5. It may not necessarily be applicable to this product.

NCBI GI #
20127446
NCBI GeneID
3693
NCBI Accession #
NP_002204.2
UniProt Primary Accession #
P18084
UniProt Secondary Accession #
B0LPF8; B2RD70
UniProt Related Accession #
P18084
GenBank Nucleotide #
NM_002213.4
NCBI Official Full Name
integrin beta-5 isoform a
NCBI Official Synonym Full Names
integrin subunit beta 5
NCBI Official Symbol
ITGB5
UniProt Protein Name
Integrin beta-5
Protein Family
Integrin
UniProt Gene Name
ITGB5
NCBI Protein Information
integrin beta-5

NCBI Summary for ITGb5

This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
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UniProt Comments for ITGb5

ITGB5: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21.2

Cellular Component: cell surface; extracellular exosome; focal adhesion; integrin alphav-beta5 complex; phagocytic vesicle; plasma membrane; receptor complex

Molecular Function: protein binding; receptor activity; viral receptor activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-matrix adhesion; endodermal cell differentiation; entry of virus into host cell; epithelial cell-cell adhesion; extracellular matrix organization; integrin-mediated signaling pathway; muscle contraction; stress fiber assembly; transforming growth factor beta receptor signaling pathway
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Research Articles on ITGb5

1. Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGb5 antibody

 Reference Product  PubMed Publications
 ITGAV antibody  >5 publications with ITGb5 and ITGAV
 ITGA5 antibody  >3 publications with ITGb5 and ITGA5
 TLN1 antibody  >1 publications with ITGb5 and TLN1

Pathways associated with anti-ITGb5 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway antibodies  Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram

Diseases associated with anti-ITGb5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with ITGb5 and Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with ITGb5 and Neoplasm Metastasis
 Inflammation Antibodies  >2 publications with ITGb5 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with ITGb5 and Breast Neoplasms
 Anemia Antibodies  >1 publications with ITGb5 and Anemia
 Neoplasms, Experimental Antibodies  >1 publications with ITGb5 and Neoplasms, Experimental
 Lung Diseases Antibodies  >1 publications with ITGb5 and Lung Diseases

Organs/Tissues associated with anti-ITGb5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with ITGb5 and Blood
 Uterus Antibodies  >4 publications with ITGb5 and Uterus
 Placenta Antibodies  >4 publications with ITGb5 and Placenta
 Vascular Antibodies  >3 publications with ITGb5 and Vascular
 Bone Marrow Antibodies  >2 publications with ITGb5 and Bone Marrow
 Stomach Antibodies  >2 publications with ITGb5 and Stomach
 Bone Antibodies  >2 publications with ITGb5 and Bone
 Lung Antibodies  >2 publications with ITGb5 and Lung
 Muscle Antibodies  >1 publications with ITGb5 and Muscle
 Prostate Antibodies  >1 publications with ITGb5 and Prostate
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