Ciliary Neurotrophic Factor (CNTF) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and Cntf sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]

CNTF: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family.

Chromosomal Location of Human Ortholog: 19 A|19 8.73 cM

Cellular Component: axon; cell soma; cytoplasm; cytosol; extracellular space; nucleus

Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; interleukin-6 receptor binding

Biological Process: astrocyte activation; cell differentiation; growth; JAK-STAT cascade; membrane hyperpolarization; multicellular organism development; muscle morphogenesis; negative regulation of neuron apoptosis; negative regulation of photoreceptor cell differentiation; nervous system development; neuron development; positive regulation of axon extension involved in regeneration; positive regulation of axon regeneration; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of hormone secretion; positive regulation of JAK-STAT cascade; positive regulation of MAPK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of STAT protein; protein heterooligomerization; regulation of resting membrane potential; regulation of retinal cell programmed cell death