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Complement 1 Inhibitor (C1INH) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2007020
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MBS2007020 is an antibody targeting C1INH. Also known as Polyclonal Antibody to Complement 1 Inhibitor (C1INH). Reactive in Mouse. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Complement 1 Inhibitor (C1INH), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Complement 1 Inhibitor (C1INH)
Product Gene Name
anti-C1INH antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: C1INH (MBS2007020)
Immunogen: C1INH (MBS2011287)
Matching Pairs
Unconjugated Antibody: C1INH (MBS2007020)
FITC Conjugated Antibody: C1INH (MBS2014274)
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3D Structure
ModBase 3D Structure for P97290
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant C1INH (Pro397~Phe495) expressed in E.coli (MBS2011287).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-C1INH antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).
Application Notes for anti-C1INH antibody
Western blotting: 0.5-2ug/mL;
Immunohistochemistry: 5-20ug/mL;
Immunocytochemistry: 5-20ug/mL;
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-C1INH antibody

Western Blot: Sample: Recombinant C1INH, Mouse.
Rabbit Anti-C1INH Polyclonal Antibody – Cat# MBS2007020

Immunohistochemistry (IHC) of anti-C1INH antibody

DAB staining on IHC-P; Samples: Mouse Ovary Tissue
Rabbit Anti-C1INH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2007020

Immunohistochemistry (IHC) of anti-C1INH antibody

DAB staining on IHC-P
Samples: Mouse Kidney Tissue
Primary Ab: 20ug/ml Rabbit Anti-Mouse C1INH Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-C1INH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2007020

Immunohistochemistry (IHC) of anti-C1INH antibody

DAB staining on IHC-P
Samples: Mouse Liver Tissue
Primary Ab: 20ug/ml Rabbit Anti-Mouse C1INH Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-C1INH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2007020

Immunohistochemistry (IHC) of anti-C1INH antibody

DAB staining on IHC-P; Samples: Mouse Testis Tissue.
Rabbit Anti-C1INH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2007020

Other Notes

Small volumes of anti-C1INH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for C1INH. It may not necessarily be applicable to this product.

NCBI GI #
163914390
NCBI GeneID
12258
NCBI Accession #
NP_033906.2
UniProt Primary Accession #
P97290
UniProt Secondary Accession #
O88330; Q99M43; Q9QX09; A2ATR7
UniProt Related Accession #
P97290
GenBank Nucleotide #
NM_009776.3
NCBI Official Full Name
plasma protease C1 inhibitor
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade G, member 1
NCBI Official Symbol
Serping1
NCBI Official Synonym Symbols
C1nh; C1INH
UniProt Protein Name
Plasma protease C1 inhibitor
UniProt Synonym Protein Names
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
UniProt Gene Name
Serping1
UniProt Synonym Gene Names
C1nh; C1 Inh; C1Inh
NCBI Protein Information
plasma protease C1 inhibitor

UniProt Comments for C1INH

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2|2 D

Cellular Component: extracellular region; extracellular space

Molecular Function: complement binding; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: blood coagulation; complement activation, classical pathway; fibrinolysis; hemostasis; immune system process; innate immune response; negative regulation of complement activation; negative regulation of complement activation, lectin pathway; negative regulation of peptidase activity; regulation of blood coagulation
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Research Articles on C1INH

1. C1INH prevented myocardial ischemia reperfusion injury in mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-C1INH antibody

 Reference Product  PubMed Publications
 C1s antibody  >19 publications with C1INH and C1s
 F12 antibody  >12 publications with C1INH and F12
 Masp2 antibody  >4 publications with C1INH and Masp2
 C1qa antibody  >2 publications with C1INH and C1qa
 Cfd antibody  >1 publications with C1INH and Cfd

Pathways associated with anti-C1INH antibody

 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway Of Fibrin Clot Formation antibodies  Intrinsic Pathway Of Fibrin Clot Formation Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram

Diseases associated with anti-C1INH antibody

 Disease Name  Pubmed Publications
 Angioedemas, Hereditary Antibodies  >133 publications with C1INH and Angioedemas, Hereditary
 Edema Antibodies  >77 publications with C1INH and Edema
 Inflammation Antibodies  >33 publications with C1INH and Inflammation
 Hereditary Angioedema Types I and II Antibodies  >26 publications with C1INH and Hereditary Angioedema Types I and II
 Acquired angioedema Antibodies  >17 publications with C1INH and Acquired angioedema
 Disease Models, Animal Antibodies  >16 publications with C1INH and Disease Models, Animal
 Necrosis Antibodies  >8 publications with C1INH and Necrosis
 Heart Diseases Antibodies  >7 publications with C1INH and Heart Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >6 publications with C1INH and Drug-Related Side Effects and Adverse Reactions
 Kidney Diseases Antibodies  >5 publications with C1INH and Kidney Diseases

Organs/Tissues associated with anti-C1INH antibody

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >57 publications with C1INH and Other
 Skin Antibodies  >31 publications with C1INH and Skin
 Eye Antibodies  >13 publications with C1INH and Eye
 Liver Antibodies  >10 publications with C1INH and Liver
 Heart Antibodies  >9 publications with C1INH and Heart
 Muscle Antibodies  >8 publications with C1INH and Muscle
 Artery Antibodies  >7 publications with C1INH and Artery
 Intestine Antibodies  >7 publications with C1INH and Intestine
 Kidney Antibodies  >6 publications with C1INH and Kidney
 Lung Antibodies  >6 publications with C1INH and Lung
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