Estrogen Receptor Beta (ERb) Antibody – Rabbit Polyclonal

ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: Nuclear receptor; DNA-binding

Cellular Component: neuron projection; mitochondrion; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; perikaryon; nucleus; cilium

Molecular Function: peroxisome proliferator activated receptor binding; ligand-dependent nuclear receptor activity; estrogen receptor activity; hormone binding; zinc ion binding; metal ion binding; estrogen response element binding; drug binding; steroid binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; lipid binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; estrogen receptor signaling pathway; behavioral fear response; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; induction of apoptosis by hormones; positive regulation of transcription, DNA-dependent; neuron migration; negative regulation of transcription from RNA polymerase II promoter; uterus development; negative regulation of cell proliferation; learning and/or memory; regulation of transcription, DNA-dependent; ovarian follicle development; positive regulation of epidermal growth factor receptor signaling pathway; regulation of neuron apoptosis; negative regulation of epithelial cell proliferation; steroid hormone receptor signaling pathway; transcription, DNA-dependent; vagina development; Sertoli cell proliferation; response to testosterone stimulus; regulation of cell proliferation; steroid hormone mediated signaling; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of behavior