Fibroblast Growth Factor 7 (FGF7) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: extracellular region; Golgi apparatus

Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: actin cytoskeleton reorganization; epidermis development; fibroblast growth factor receptor signaling pathway; hair follicle morphogenesis; MAPK cascade; mesenchymal cell proliferation; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of keratinocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-templated; regulation of phosphatidylinositol 3-kinase signaling; response to wounding; signal transduction