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Syndecan 4 (SDC4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2025903
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MBS2025903 is an antibody targeting SDC4. Also known as Polyclonal Antibody to Syndecan 4 (SDC4). Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Syndecan 4 (SDC4), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Syndecan 4 (SDC4)
Product Gene Name
anti-SDC4 antibody
Clonality
Polyclonal
Host
Rabbit
Form/Format
Liquid; Supplied as solution form in 0.01M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.39mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 24 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: SDC4 (MBS2025903)
Immunogen: SDC4 (MBS2029621)
Matching Pairs
Unconjugated Antibody: SDC4 (MBS2025903)
APC-CY7 Conjugated Antibody: SDC4 (MBS2060818)
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OMIM
X67016 mRNA
3D Structure
ModBase 3D Structure for P31431
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Cross Reactivity
Mouse
Immunogen
Recombinant SDC4 (Ala18~Glu145) expressed in E.coli
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-SDC4 antibody
Western Blot (WB)
Application Notes for anti-SDC4 antibody
Western blotting: 0.01-2ug/mL

Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-SDC4 antibody

Western Blot: Sample: Lane1: Human Liver Tissue; Lane2: Human 293T Cells; Lane3: Mouse Kidney Tissue.
Rabbit Anti-SDC4 Polyclonal Antibody – Cat# MBS2025903

Western Blot (WB) of anti-SDC4 antibody

Western Blot: Sample: Recombinant SDC4, Human.
Rabbit Anti-SDC4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2025903

Immunohistochemistry (IHC) of anti-SDC4 antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-SDC4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2025903

Western Blot (WB) of anti-SDC4 antibody

Western Blot;
Sample:
Lane1: 293T cell lysate;
Lane2: Human Liver lysate;
Lane3: Mouse Kidney lysate;
Lane4: Mouse Cerebrum lysate;
Lane5: Mouse Cerebellum lysate
Primary Ab: 1.2ug/ml Rabbit Anti-Human SDC4 Antibody
Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-SDC4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2025903

Other Notes

Small volumes of anti-SDC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SDC4. It may not necessarily be applicable to this product.

NCBI GI #
38201675
NCBI GeneID
6385
NCBI Accession #
NP_002990.2
UniProt Primary Accession #
P31431
UniProt Secondary Accession #
O00773; Q16833; Q53FN9; Q6FGN3
UniProt Related Accession #
P31431
GenBank Nucleotide #
NM_002999.3
NCBI Official Full Name
syndecan-4
NCBI Official Synonym Full Names
syndecan 4
NCBI Official Symbol
SDC4
NCBI Official Synonym Symbols
SYND4
UniProt Protein Name
Syndecan-4
UniProt Synonym Protein Names
Amphiglycan; Ryudocan core protein
Protein Family
Syndecan
UniProt Gene Name
SDC4
UniProt Synonym Gene Names
SYND4
NCBI Protein Information
syndecan-4

NCBI Summary for SDC4

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
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UniProt Comments for SDC4

syndecan-4: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: cell surface; costamere; extracellular exosome; focal adhesion; Golgi lumen; integral component of plasma membrane; lysosomal lumen; membrane raft; plasma membrane

Molecular Function: fibronectin binding; identical protein binding; protein binding; protein kinase C binding

Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; inner ear receptor stereocilium organization and biogenesis; leukocyte migration; negative regulation of T cell proliferation; neural tube closure; positive regulation of focal adhesion assembly; positive regulation of protein kinase activity; positive regulation of stress fiber formation; regulation of fibroblast migration; retinoid metabolic process; signal transduction; ureteric bud development; wound healing
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Research Articles on SDC4

1. This study demonstrates that the shedding of synd4 from Endothelial progenitor cells (EPCs) plays a key role in advanced glycation end products-mediated dysfunction of EPC migration and homing.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SDC4 antibody

 Reference Product  PubMed Publications
 PRKCA antibody  >21 publications with SDC4 and PRKCA
 CXCR4 antibody  >5 publications with SDC4 and CXCR4
 CCL5 antibody  >4 publications with SDC4 and CCL5
 PRKCD antibody  >3 publications with SDC4 and PRKCD
 CASK antibody  >3 publications with SDC4 and CASK
 GIPC1 antibody  >1 publications with SDC4 and GIPC1

Pathways associated with anti-SDC4 antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 HS-GAG Biosynthesis Pathway antibodies  HS-GAG Biosynthesis Pathway Diagram

Diseases associated with anti-SDC4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >34 publications with SDC4 and Neoplasms
 Inflammation Antibodies  >19 publications with SDC4 and Inflammation
 Necrosis Antibodies  >15 publications with SDC4 and Necrosis
 Cardiovascular Diseases Antibodies  >14 publications with SDC4 and Cardiovascular Diseases
 Fibrosis Antibodies  >10 publications with SDC4 and Fibrosis
 Nervous System Diseases Antibodies  >8 publications with SDC4 and Nervous System Diseases
 Brain Diseases Antibodies  >7 publications with SDC4 and Brain Diseases
 Liver Diseases Antibodies  >6 publications with SDC4 and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with SDC4 and Kidney Diseases
 Breast Neoplasms Antibodies  >4 publications with SDC4 and Breast Neoplasms

Organs/Tissues associated with anti-SDC4 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >42 publications with SDC4 and Vascular
 Muscle Antibodies  >36 publications with SDC4 and Muscle
 Skin Antibodies  >19 publications with SDC4 and Skin
 Bone Antibodies  >17 publications with SDC4 and Bone
 Kidney Antibodies  >16 publications with SDC4 and Kidney
 Embryonic Tissue Antibodies  >16 publications with SDC4 and Embryonic Tissue
 Liver Antibodies  >13 publications with SDC4 and Liver
 Heart Antibodies  >13 publications with SDC4 and Heart
 Brain Antibodies  >13 publications with SDC4 and Brain
 Lung Antibodies  >12 publications with SDC4 and Lung
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