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SLCO1A2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS612324

MBS612324 is an antibody targeting SLCO1A2. Also known as OATP1 (Organic Anion Transporting Polypeptide 1). Reactive in Mouse, Rat. Host: Rabbit. More details

$995 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OATP1 (SLCO1A2), Polyclonal Antibody
Full Product Name
OATP1 (Organic Anion Transporting Polypeptide 1)
Product Gene Name
anti-SLCO1A2 antibody
Product Synonym Names
Anti -OATP1 (Organic Anion Transporting Polypeptide 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% BSA.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes rat Organic Anion Transporting Polypeptide 1 (OATP1). The immunogen shows no significant sequence homology with other OATPs or other proteins. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol 40-50%, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
74,145 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (21417534..21548371, complement). Location: 12p12
OMIM
602883
3D Structure
ModBase 3D Structure for P46721
Immunogen
A 17 amino acid peptide sequence near aa285 of rat OATP1.

Product Categories/Family for anti-SLCO1A2 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-SLCO1A2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SLCO1A2 antibody
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-10ug/ml using ECL.
ELISA: 0.5-1ug/ml. Using 1ug/ml immunogen per well.

Other Notes

Small volumes of anti-SLCO1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLCO1A2. It may not necessarily be applicable to this product.

NCBI GI #
9188296
NCBI GeneID
6579
UniProt Primary Accession #
P46721
UniProt Secondary Accession #
Q9UGP7; Q9UL38
UniProt Related Accession #
P46721; Q8IV69
NCBI Official Full Name
organic anion transporting polypeptide 1 (OATP1)
NCBI Official Synonym Full Names
solute carrier organic anion transporter family, member 1A2
NCBI Official Symbol
SLCO1A2
NCBI Official Synonym Symbols
OATP; OATP-A; OATP1A2; SLC21A3
UniProt Protein Name
Solute carrier organic anion transporter family member 1A2
UniProt Synonym Protein Names
OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3
Protein Family
Solute carrier organic anion transporter family
UniProt Gene Name
SLCO1A2
UniProt Synonym Gene Names
OATP; OATP1; OATP1A2; SLC21A3
UniProt Entry Name
SO1A2_HUMAN
NCBI Protein Information
solute carrier organic anion transporter family member 1A2; OATP-1; OTTHUMP00000209604; OTTHUMP00000209605; solute carrier family 21 member 3; organic anion transporting polypeptide A; organic anion-transporting polypeptide 1; sodium-independent organic anion transporter; solute carrier family 21 (organic anion transporter), member 3

NCBI Summary for SLCO1A2

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
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UniProt Comments for SLCO1A2

SLCO1A2: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: integral to membrane; plasma membrane

Molecular Function: organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport
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Research Articles on SLCO1A2

1. Although imatinib is indicated as a substrate for OATP1A2, this transporter by itself is unlikely to contribute substantially to the absorption profiles of imatinib in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLCO1A2 antibody

 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Recycling Of Bile Acids And Salts Pathway antibodies  Recycling Of Bile Acids And Salts Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Organic Anions Pathway antibodies  Transport Of Organic Anions Pathway Diagram
 Transport Of Vitamins, Nucleosides, And Related Molecules Pathway antibodies  Transport Of Vitamins, Nucleosides, And Related Molecules Pathway Diagram

Diseases associated with anti-SLCO1A2 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with SLCO1A2 and Liver Diseases
 Drug Toxicity Antibodies  >3 publications with SLCO1A2 and Drug Toxicity
 Kidney Diseases Antibodies  >2 publications with SLCO1A2 and Kidney Diseases
 Breast Neoplasms Antibodies  >2 publications with SLCO1A2 and Breast Neoplasms
 Epilepsy Antibodies  >1 publications with SLCO1A2 and Epilepsy
 Fibrosis Antibodies  >1 publications with SLCO1A2 and Fibrosis
 Kidney Neoplasms Antibodies  >1 publications with SLCO1A2 and Kidney Neoplasms
 Autoimmune Diseases Antibodies  >1 publications with SLCO1A2 and Autoimmune Diseases
 Neoplasms, Hormone-Dependent Antibodies  >1 publications with SLCO1A2 and Neoplasms, Hormone-Dependent
 Pregnancy Complications Antibodies  >1 publications with SLCO1A2 and Pregnancy Complications

Organs/Tissues associated with anti-SLCO1A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with SLCO1A2 and Liver
 Kidney Antibodies  >11 publications with SLCO1A2 and Kidney
 Brain Antibodies  >11 publications with SLCO1A2 and Brain
 Mouth Antibodies  >1 publications with SLCO1A2 and Mouth
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