Translin (TSN) Antibody – Rabbit Polyclonal

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

TSN: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Belongs to the translin family.

Protein type: Nuclear receptor co-regulator; EC 3.1.-.-; DNA-binding

Chromosomal Location of Human Ortholog: 2q21.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: mRNA binding; endoribonuclease activity; protein binding; DNA binding; sequence-specific DNA binding; protein complex binding; single-stranded DNA binding

Biological Process: gene expression; DNA recombination