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UBE2E3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630403

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s,… More details

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Product Overview

Online Datasheet in PDF
Product Name
UBCH9 (UBE2E3), Polyclonal Antibody
Full Product Name
UBCH9, NT (Ubiquitin-conjugating Enzyme E2 E3, Ubiquitin-protein Ligase E3, Ubiquitin Carrier Protein E3, Ubiquitin-conjugating Enzyme E2-23kD, UbcH9, UBE2E3, UBCE4)
Product Gene Name
anti-UBE2E3 antibody
Product Synonym Names
Anti -UBCH9, NT (Ubiquitin-conjugating Enzyme E2 E3, Ubiquitin-protein Ligase E3, Ubiquitin Carrier Protein E3, Ubiquitin-conjugating Enzyme E2-23kD, UbcH9, UBE2E3, UBCE4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human UBCH9. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
22,913 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (181845112..181928154). Location: 2q32.1
OMIM
604151
3D Structure
ModBase 3D Structure for Q969T4
Immunogen
Synthetic peptide selected from the N-terminal region of human UBCH9 (KLH).

Product Categories/Family for anti-UBE2E3 antibody

Antibodies; Abs to Ubiquitin Ligases
Applications Tested/Suitable for anti-UBE2E3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-UBE2E3 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-UBE2E3 antibody

Western blot analysis of anti-UBCH9 Antibody (N-term) in Y79 cell line lysates (35ug/lane). UBCH9 (arrow) was detected using the purified Pab.
Rabbit Anti-UBE2E3 Polyclonal Antibody – Cat# MBS630403

Immunohistochemistry (IHC) of anti-UBE2E3 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-UBE2E3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630403

Other Notes

Small volumes of anti-UBE2E3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBE2E3 purchase

MBS630403 is an antibody targeting UBE2E3. Also known as UBCH9, NT (Ubiquitin-conjugating Enzyme E2 E3, Ubiquitin-protein Ligase E3, Ubiquitin Carrier Protein E3, Ubiquitin-conjugating Enzyme E2-23kD, UbcH9, UBE2E3, UBCE4). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UBE2E3. It may not necessarily be applicable to this product.

NCBI GI #
514052667
NCBI GeneID
10477
NCBI Accession #
NP_001265484.1
UniProt Primary Accession #
Q969T4
UniProt Secondary Accession #
Q5U0R7; Q7Z4W4; B2RAD6; D3DPG3
UniProt Related Accession #
Q969T4
GenBank Nucleotide #
NM_001278555.1
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 E3
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2E 3
NCBI Official Symbol
UBE2E3
NCBI Official Synonym Symbols
UBCH9; UbcM2
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 E3
UniProt Synonym Protein Names
UbcH9; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; Ubiquitin-protein ligase E3
Protein Family
Ubiquitin-conjugating enzyme
UniProt Gene Name
UBE2E3
UniProt Synonym Gene Names
UBCE4; UBCH9
UniProt Entry Name
UB2E3_HUMAN
NCBI Protein Information
ubiquitin-conjugating enzyme E2 E3; ubiquitin-protein ligase E3; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme E2-23 kDa; ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5)

NCBI Summary for UBE2E3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
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UniProt Comments for UBE2E3

UBE2E3: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: cytoplasm; nucleus

Molecular Function: ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: regulation of growth
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Research Articles on UBE2E3

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBE2E3 antibody

 Reference Product  PubMed Publications
 DNAJA1 antibody  >1 publications with UBE2E3 and DNAJA1

Pathways associated with anti-UBE2E3 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with anti-UBE2E3 antibody

 Disease Name  Pubmed Publications
 Musculoskeletal Diseases Antibodies  >1 publications with UBE2E3 and Musculoskeletal Diseases
 Nervous System Diseases Antibodies  >1 publications with UBE2E3 and Nervous System Diseases
 Adenocarcinoma Antibodies  >1 publications with UBE2E3 and Adenocarcinoma
 Weight Loss Antibodies  >1 publications with UBE2E3 and Weight Loss

Organs/Tissues associated with anti-UBE2E3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with UBE2E3 and Blood
 Embryonic Tissue Antibodies  >1 publications with UBE2E3 and Embryonic Tissue
 Muscle Antibodies  >1 publications with UBE2E3 and Muscle
 Brain Antibodies  >1 publications with UBE2E3 and Brain
 Eye Antibodies  >1 publications with UBE2E3 and Eye
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