ARHGDIA Antibody – Rabbit

Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI). RhoGDI affects Rho activity by inhibiting nucleotide exchange and membrane association, regulating activity and localization (Reviewed in 1, 2). The inhibitory and shuttling functions of RhoGDI have been uncoupled using mutant forms of RhoGDI (3). Phosphorylation of GDIs and/or GTPases can modulate their affinity for each other and, therefore, GTPase mediated signaling. PAK1 phosphorylation of RhoGDI at serines 101 and 174 causes release and activation of Rac1, but not RhoA (4).

1. DerMardirossian, C. and Bokoch, G. (2005) Trends Cell Biol. 15, 356-363. 2.Dovas, A. and Couchman, J.R. (2005) RhoGDI: multiple functions in the regulation of Rho familyGTPase activities. Biochem. J. 390, 1-9. 3. Dransart, E. et al. (2005) J. Biol. Chem. 280, 4674-4683. 4. DerMardirossian, C. et al. (2004) Mol. Cell 15, 117-127.

Small volumes of anti-ARHGDIA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8500315 is an antibody targeting ARHGDIA. Also known as ARHGDIA Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.