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IL17A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS220191

Rabbit anti Human Interleukin-17 antibody recognizes human IL-17 (Interleukin-17/17A), a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL-17 (IL17A), Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN INTERLEUKIN-17:Biotin
Product Gene Name
anti-IL17A antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Biotin
Purified IgG conjugated to Biotin - lyophilised
Concentration
IgG concentration 0.1 mg/ml after reconstitution (lot specific)
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Molecular Weight
17,504 Da
OMIM
603149
3D Structure
ModBase 3D Structure for Q16552
Reconstitution
Reconstitute with 0.5 ml sterile PBS containing 0.1% Bovine Serum Albumin. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
Buffer Solution
Phosphate buffered saline
Antiserum Preparation
Antisera to human IL-17 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-IL17A antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-IL17A antibody
ELISA: This biotinylated human IL-17 antibody may be used in a direct ELISA or as the detection reagent in a sandwich ELISA with our purified human IL-17 antibody as the capture reagent and recombinant human IL-17 as the standard.
Western Blot: This antibody may be used in Western Blotting under either reducing or non-reducing conditions with recombinant human IL-17 as the positive control.
ELISA: Minimum Dilution: 0.25; Maximum Dilution: 1.0ug/ml
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

Testing Data #1 of anti-IL17A antibody

Staining of formalin fixed,paraffin embedded human breast invasive ductal carcinoma with Rabbit anti Human interleukin-17 (MBS221587)
Rabbit Anti-IL17A Polyclonal Antibody – Cat# MBS220191

Testing Data #2 of anti-IL17A antibody

Formalin fixed, paraffin embedded human breast invasive ductal carcinoma stained with Goat anti Human IL-17A (MBS221587) following heat mediated antigen retrieval with sodium citrate buffer (pH6.0)
Rabbit Anti-IL17A Polyclonal Antibody, Testing Data #2 – Cat# MBS220191

Other Notes

Small volumes of anti-IL17A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17A purchase

MBS220191 is an antibody targeting IL17A. Also known as RABBIT ANTI HUMAN INTERLEUKIN-17:Biotin. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17A. It may not necessarily be applicable to this product.

NCBI GI #
4504651
NCBI GeneID
3605
NCBI Accession #
NP_002181.1
UniProt Primary Accession #
Q16552
UniProt Secondary Accession #
Q5T2P0
UniProt Related Accession #
Q16552
GenBank Nucleotide #
NM_002190.2
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; IL-17A
UniProt Protein Name
Interleukin-17A
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family
Interleukin
UniProt Gene Name
IL17A
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8
UniProt Entry Name
IL17_HUMAN
NCBI Protein Information
interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

NCBI Summary for IL17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL17A

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; protein amino acid glycosylation; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
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Research Articles on IL17A

1. IL-19 as a component of the IL-23/IL-17 axis strengthens the IL-17A action and might be a biomarker for the activity of this axis in chronic inflammatory disorders

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL17A antibody

 Reference Product  PubMed Publications
 FOXP3 antibody  >679 publications with IL17A and FOXP3
 STAT3 antibody  >288 publications with IL17A and STAT3
 TGFB1 antibody  >150 publications with IL17A and TGFB1
 IL6 antibody  >120 publications with IL17A and IL6
 IL17RA antibody  >117 publications with IL17A and IL17RA
 STAT1 antibody  >89 publications with IL17A and STAT1
 IL23A antibody  >71 publications with IL17A and IL23A
 IL17RC antibody  >26 publications with IL17A and IL17RC
 NFKB1 antibody  >3 publications with IL17A and NFKB1

Pathways associated with anti-IL17A antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL17 Signaling Pathway antibodies  IL17 Signaling Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram

Diseases associated with anti-IL17A antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2520 publications with IL17A and Inflammation
 Autoimmune Diseases Antibodies  >1893 publications with IL17A and Autoimmune Diseases
 Disease Models, Animal Antibodies  >1359 publications with IL17A and Disease Models, Animal
 Necrosis Antibodies  >1050 publications with IL17A and Necrosis
 Respiratory Tract Diseases Antibodies  >743 publications with IL17A and Respiratory Tract Diseases
 Lung Diseases Antibodies  >653 publications with IL17A and Lung Diseases
 Central Nervous System Diseases Antibodies  >553 publications with IL17A and Central Nervous System Diseases
 Hypersensitivity Antibodies  >521 publications with IL17A and Hypersensitivity
 Liver Diseases Antibodies  >202 publications with IL17A and Liver Diseases
 Fibrosis Antibodies  >182 publications with IL17A and Fibrosis

Organs/Tissues associated with anti-IL17A antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >107 publications with IL17A and Mixed
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