PKC Alpha (PRKCA) Antibody – Rabbit Polyclonal

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators.

Protein type: EC 2.7.11.13; Protein kinase, AGC; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 17q22-q23.2

Cellular Component: apical part of cell; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; mitochondrial membrane; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; photoreceptor outer segment; plasma membrane

Molecular Function: ATP binding; calcium-dependent protein kinase C activity; enzyme binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity; zinc ion binding

Biological Process: adenylate cyclase activation; angiogenesis; blood coagulation; cell adhesion; cellular calcium ion homeostasis; chondrocyte differentiation; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; gene expression; inactivation of MAPK activity; induction of positive chemotaxis; innate immune response; mitotic cell cycle; mitotic nuclear envelope disassembly; negative regulation of adenylate cyclase activity; negative regulation of cell proliferation; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; neutrophil chemotaxis; peptidyl-serine phosphorylation; phospholipase C activation; phototransduction, visible light; platelet activation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of inflammatory response; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; regulation of insulin secretion; regulation of mRNA stability; regulation of muscle contraction; regulation of peptidyl-tyrosine phosphorylation; regulation of rhodopsin mediated signaling; regulation of the force of heart contraction; rhodopsin mediated signaling; signal transduction; synaptic transmission; vascular endothelial growth factor receptor signaling pathway