• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PPP1R15A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416924

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
PPP1R15A, Polyclonal Antibody
Full Product Name
Anti-PPP1R15A Antibody
Product Gene Name
anti-PPP1R15A antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
56,515 Da
OMIM
611048
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Immunogen
Rabbit polyclonal PPP1R15A (1) antibody was raised against a recombinate human PPP1R15A protein 115-211aa (BC003067).
Applications Tested/Suitable for anti-PPP1R15A antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PPP1R15A antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user

Testing Data of anti-PPP1R15A antibody

Rabbit Anti-PPP1R15A Polyclonal Antibody – Cat# MBS416924

Testing Data of anti-PPP1R15A antibody

Rabbit Anti-PPP1R15A Polyclonal Antibody, Testing Data – Cat# MBS416924

Product References and Citations for anti-PPP1R15A antibody

(1) Zhou,W., Brush,M.H., Choy,M.S. and Shenolikar,S. Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. J. Biol. Chem. 286 (24), 21687-21696 (2011)

Other Notes

Small volumes of anti-PPP1R15A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP1R15A purchase

MBS416924 is an antibody targeting PPP1R15A. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP1R15A. It may not necessarily be applicable to this product.

NCBI GI #
33869516
NCBI GeneID
23645
NCBI Accession #
BC003067
UniProt Secondary Accession #
Q6IA96; Q9NVU6; B4DKQ3
UniProt Related Accession #
O75807
NCBI Official Full Name
Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 15A, mRNA
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory subunit 15A
NCBI Official Symbol
PPP1R15A
NCBI Official Synonym Symbols
GADD34
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 15A
UniProt Synonym Protein Names
Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog
Protein Family
Protein phosphatase 1 regulatory
UniProt Gene Name
PPP1R15A
UniProt Entry Name
PR15A_HUMAN
NCBI Protein Information
protein phosphatase 1 regulatory subunit 15A; growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response protein MyD116 homolog; protein phosphatase 1, regulatory (inhibitor) subunit 15A

UniProt Comments for PPP1R15A

GADD34: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Belongs to the PPP1R15 family.

Protein type: DNA repair, damage; Cell cycle regulation; Translation initiation; Apoptosis

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; protein phosphatase type 1 complex; cytosol

Molecular Function: protein binding; protein phosphatase type 1 regulator activity; protein kinase binding; protein phosphatase 1 binding

Biological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of phosphoprotein phosphatase activity; unfolded protein response; apoptosis; transforming growth factor beta receptor signaling pathway; negative regulation of phosphoprotein phosphatase activity; positive regulation of translation initiation in response to stress; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; response to DNA damage stimulus; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase I promoter
Show more

Research Articles on PPP1R15A

1. Nuclear export of HTLV-1 basic leucine-zipper factor (HBZ) is essential for its interaction with GADD34 and increased phosphorylation of S6 kinase, which is an established downstream target of the mTOR pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP1R15A antibody

 Reference Product  PubMed Publications
 ATF4 antibody  >24 publications with PPP1R15A and ATF4
 SMARCB1 antibody  >3 publications with PPP1R15A and SMARCB1
 KIF3A antibody  >1 publications with PPP1R15A and KIF3A
 SMAD7 antibody  >1 publications with PPP1R15A and SMAD7

Pathways associated with anti-PPP1R15A antibody

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram

Diseases associated with anti-PPP1R15A antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >17 publications with PPP1R15A and Necrosis
 Nervous System Diseases Antibodies  >15 publications with PPP1R15A and Nervous System Diseases
 Disease Models, Animal Antibodies  >14 publications with PPP1R15A and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >8 publications with PPP1R15A and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >7 publications with PPP1R15A and Neoplasms, Experimental
 Inflammation Antibodies  >6 publications with PPP1R15A and Inflammation
 Liver Diseases Antibodies  >6 publications with PPP1R15A and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with PPP1R15A and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >3 publications with PPP1R15A and Breast Neoplasms
 Fatty Liver Antibodies  >3 publications with PPP1R15A and Fatty Liver

Organs/Tissues associated with anti-PPP1R15A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with PPP1R15A and Blood
 Liver Antibodies  >14 publications with PPP1R15A and Liver
 Brain Antibodies  >14 publications with PPP1R15A and Brain
 Vascular Antibodies  >6 publications with PPP1R15A and Vascular
 Nerve Antibodies  >5 publications with PPP1R15A and Nerve
 Heart Antibodies  >5 publications with PPP1R15A and Heart
 Lung Antibodies  >5 publications with PPP1R15A and Lung
 Skin Antibodies  >4 publications with PPP1R15A and Skin
 Bone Antibodies  >4 publications with PPP1R15A and Bone
 Muscle Antibodies  >4 publications with PPP1R15A and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000