Cavy SPTbetaN4 ELISA Kit – Cat# MBS057744

Spectrin Beta, Non Erythrocytic 4 (SPTbetaN4) ELISA Kit for Cavy

Name: Cavy SPTbetaN4 ELISA Kit; Spectrin Beta, Non Erythrocytic 4; MyBioSource
Brand: MyBioSource
SKU: MBS057744
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS057744

MBS057744 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Spectrin Beta, Non Erythrocytic 4 (SPTbetaN4) ELISA Kit target analytes in biological samples. The concentration… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Spectrin Beta, Non Erythrocytic 4 (SPTbetaN4), ELISA Kit

Full Product Name

Cavy Spectrin Beta, Non Erythrocytic 4 ELISA Kit

Product Gene Name

SPTbetaN4 elisa kit

Species Reactivity

Cavy

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

246,468 Da

OMIM

130600

3D Structure

ModBase 3D Structure for P11277

Other Notes

Small volumes of SPTbetaN4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPTbetaN4. It may not necessarily be applicable to this product.

NCBI GI #

67782321

NCBI GeneID

6710

NCBI Accession #

NP_001020029.1

UniProt Primary Accession #

P11277

UniProt Secondary Accession #

Q15510; Q15519

UniProt Related Accession #

P11277

GenBank Nucleotide #

NM_001024858.2

NCBI Official Full Name

spectrin beta chain, erythrocytic isoform a

NCBI Official Synonym Full Names

spectrin, beta, erythrocytic

NCBI Official Symbol

SPTB

NCBI Official Synonym Symbols

EL3; HS2; SPH2; HSPTB1

UniProt Protein Name

Spectrin beta chain, erythrocytic

UniProt Synonym Protein Names

Beta-I spectrin

UniProt Gene Name

SPTB

UniProt Synonym Gene Names

SPTB1

UniProt Entry Name

SPTB1_HUMAN

NCBI Protein Information

spectrin beta chain, erythrocytic; beta-I spectrin; membrane cytoskeletal protein; spectrin beta chain, erythrocyte

NCBI Summary for SPTbetaN4

This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

UniProt Comments for SPTbetaN4

SPTB1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTB are the cause of elliptocytosis type 3 (EL3). EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTB are the cause of spherocytosis type 2 (SPH2); also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q23-q24.2

Cellular Component: spectrin; cell surface; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; protein heterodimerization activity; ankyrin binding; actin binding

Biological Process: axon guidance; plasma membrane organization and biogenesis; actin filament capping; hemopoiesis; porphyrin biosynthetic process

Disease: Spherocytosis, Type 2, Included

Research Articles on SPTbetaN4

1. analysis of glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SPTbetaN4 elisa kit

Reference Product	PubMed Publications
ANK1 elisa kit	>10 publications with SPTbetaN4 and ANK1
SPTA1 elisa kit	>8 publications with SPTbetaN4 and SPTA1
SPTBN1 elisa kit	>1 publications with SPTbetaN4 and SPTBN1

Pathways associated with SPTbetaN4 elisa kit

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Interaction Between L1 And Ankyrins Pathway antibodies	Interaction Between L1 And Ankyrins Pathway Diagram
L1CAM Interactions Pathway antibodies	L1CAM Interactions Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram

Diseases associated with SPTbetaN4 elisa kit

Disease Name	Pubmed Publications
Spherocytosis, Hereditary Antibodies	>16 publications with SPTbetaN4 and Spherocytosis, Hereditary
Inflammation Antibodies	>14 publications with SPTbetaN4 and Inflammation
Anemia, Hemolytic Antibodies	>14 publications with SPTbetaN4 and Anemia, Hemolytic
Elliptocytosis, Hereditary Antibodies	>7 publications with SPTbetaN4 and Elliptocytosis, Hereditary
Nervous System Diseases Antibodies	>4 publications with SPTbetaN4 and Nervous System Diseases
Necrosis Antibodies	>4 publications with SPTbetaN4 and Necrosis
Hemolysis Antibodies	>3 publications with SPTbetaN4 and Hemolysis
Neoplasms Antibodies	>2 publications with SPTbetaN4 and Neoplasms
Edema Antibodies	>2 publications with SPTbetaN4 and Edema
Disease Models, Animal Antibodies	>2 publications with SPTbetaN4 and Disease Models, Animal

Organs/Tissues associated with SPTbetaN4 elisa kit

Organ/Tissue Name	Pubmed Publications
Uterus Antibodies	>12 publications with SPTbetaN4 and Uterus
Placenta Antibodies	>11 publications with SPTbetaN4 and Placenta
Nerve Antibodies	>2 publications with SPTbetaN4 and Nerve
Heart Antibodies	>2 publications with SPTbetaN4 and Heart
Lung Antibodies	>2 publications with SPTbetaN4 and Lung
Muscle Antibodies	>2 publications with SPTbetaN4 and Muscle
Embryonic Tissue Antibodies	>2 publications with SPTbetaN4 and Embryonic Tissue
Spleen Antibodies	>2 publications with SPTbetaN4 and Spleen
Brain Antibodies	>2 publications with SPTbetaN4 and Brain
Mouth Antibodies	>1 publications with SPTbetaN4 and Mouth