Transforming Growth Factor Beta-2 (TGFB2) ELISA Kit for Mouse

TGFB2: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cell development/differentiation; Motility/polarity/chemotaxis; Secreted

Cellular Component: axon; basement membrane; cell soma; cell surface; cytoplasm; endosome; extracellular matrix; extracellular region; extracellular space; secretory granule; trans-Golgi network

Molecular Function: beta-amyloid binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding; punt binding; receptor binding; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta receptor binding

Biological Process: activation of protein kinase activity; axon guidance; blood vessel development; blood vessel remodeling; cardiac muscle cell proliferation; cardioblast differentiation; cartilage condensation; catagen; cell cycle arrest; cell death; cell growth; cell migration; cell morphogenesis; collagen fibril organization; dopamine biosynthetic process; embryonic neurocranium morphogenesis; epithelial to mesenchymal transition; extracellular matrix organization and biogenesis; eye development; glial cell migration; growth; hair follicle development; hair follicle morphogenesis; heart development; heart morphogenesis; hemopoiesis; intercellular junction assembly and maintenance; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of immune response; negative regulation of keratinocyte differentiation; negative regulation of release of sequestered calcium ion into cytosol; neuron development; neuron fate commitment; positive regulation of apoptosis; positive regulation of cardioblast differentiation; positive regulation of catagen; positive regulation of cell adhesion mediated by integrin; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of integrin biosynthetic process; positive regulation of neuron apoptosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein secretion; positive regulation of stress-activated MAPK cascade; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; regulation of transforming growth factor-beta2 production; response to drug; response to estrogen stimulus; response to hypoxia; response to progesterone stimulus; skeletal development; SMAD protein nuclear translocation; somatic stem cell division; transforming growth factor beta receptor signaling pathway; wound healing