T-cell differentiation antigen
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
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T-cell differentiation antigen CD6
CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.
Protein type: Cell surface; Membrane protein, integral
Cellular Component: immunological synapse; intrinsic to plasma membrane; T cell receptor complex
Molecular Function: glycoprotein binding; lipopolysaccharide binding; protein binding; protein kinase binding
Biological Process: acute inflammatory response to antigenic stimulus; formation of immunological synapse; heterophilic cell adhesion; lipopolysaccharide-mediated signaling pathway; positive regulation of protein amino acid phosphorylation; positive regulation of T cell proliferation; response to lipopolysaccharide
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