SERPINI1 Active Protein – Cat# MBS539613

Neuroserpin (SERPINI1) Active Protein

Name: SERPINI1 Active Protein; Neuroserpin; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS539613
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS539613

MBS539613 is an active protein targeting SERPINI1. Also known as Neuroserpin protein. Host: Human. Purified recombinant Human Neuroserpin protein More details

$685 / 0.025 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neuroserpin (SERPINI1), Active Protein

Full Product Name

Neuroserpin protein

Product Gene Name

SERPINI1 active protein

Product Synonym Names

Serpin I1 protein; Protease inhibitor 12 protein

Sequence

Region of Neuroserpi n protein correspond ing to amino acids MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL.

Host

Human

Form/Format

Supplied as a lyophilized powder.

Purity/Purification

> 96% pure

Preparation and Storage

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Molecular Weight

44.6 kDa

OMIM

602445

3D Structure

ModBase 3D Structure for Q99574

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Protein Type

Recombinant

Bioactivity

Determined by the dose-dependent stimulation of the proliferation of rat C6 cells using a concentration range of 0.3-0.6 ug/ml.

Endotoxin Levels

Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System

E Coli

Product Categories/Family for SERPINI1 active protein

Neuroscience

Applications Tested/Suitable for SERPINI1 active protein

User optimized

Other Notes

Small volumes of SERPINI1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINI1. It may not necessarily be applicable to this product.

NCBI GI #

1785654

NCBI Accession #

CAB03626.1

UniProt Primary Accession #

Q99574

UniProt Secondary Accession #

Q6AHZ4; A8K217; D3DNP1

NCBI Official Full Name

neuroserpin

UniProt Protein Name

Neuroserpin

UniProt Synonym Protein Names

Peptidase inhibitor 12; PI-12; Serpin I1

Protein Family

Neuroserpin

UniProt Gene Name

SERPINI1

UniProt Synonym Gene Names

PI12; PI-12

UniProt Entry Name

NEUS_HUMAN

UniProt Comments for SERPINI1

SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development

Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SERPINI1 active protein

Reference Product	PubMed Publications
PDCD10 active protein	>2 publications with SERPINI1 and PDCD10
MYC active protein	>2 publications with SERPINI1 and MYC

Diseases associated with SERPINI1 active protein

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>4 publications with SERPINI1 and Mental Disorders
Liver Diseases Antibodies	>3 publications with SERPINI1 and Liver Diseases
Schizophrenia Antibodies	>1 publications with SERPINI1 and Schizophrenia
Seizures Antibodies	>1 publications with SERPINI1 and Seizures
Movement Disorders Antibodies	>1 publications with SERPINI1 and Movement Disorders
Cardiovascular Diseases Antibodies	>1 publications with SERPINI1 and Cardiovascular Diseases
Myoclonic Epilepsies, Progressive Antibodies	>1 publications with SERPINI1 and Myoclonic Epilepsies, Progressive
Familial encephalopathy with neuroserpin inclusion bodies Antibodies	>1 publications with SERPINI1 and Familial encephalopathy with neuroserpin inclusion bodies

Organs/Tissues associated with SERPINI1 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>10 publications with SERPINI1 and Brain
Liver Antibodies	>4 publications with SERPINI1 and Liver
Intestine Antibodies	>1 publications with SERPINI1 and Intestine
Stomach Antibodies	>1 publications with SERPINI1 and Stomach
Muscle Antibodies	>1 publications with SERPINI1 and Muscle
Embryonic Tissue Antibodies	>1 publications with SERPINI1 and Embryonic Tissue