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Alpha Synuclein (SNCA) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8001848

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally,… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Alpha Synuclein (Snca), Active Protein
Full Product Name
Alpha Synuclein Protein
Product Gene Name
Snca active protein
Product Synonym Names
Active Mouse Recombinant Alpha Synuclein Protein Aggregates (Pre-formed Fibrils); Alpha synuclein pre-formed fibrils; Alpha synuclein aggregates; Alpha synuclein protein aggregates; Active Alpha synuclein aggregates; Alpha-synuclein protein; Non-A beta component of AD amyloid protein; Non-A4 component of amyloid precursor protein; NACP protein; SNCA protein; NACP protein; PARK1 protein; Alpha synuclein monomers; SYN protein; Parkison disease familial 1 Protein
Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
Host
E Coli
Purity/Purification
>95%
Ion-exchange Purified
Specificity
~14.46 kDa
Preparation and Storage
Store at -80 degree C.
Molecular Weight
12,345 Da
3D Structure
ModBase 3D Structure for O55042
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Mouse
Target
Alpha Synuclein
Cellular Localization
Cytoplasm; Membrane; Nucleus
Storage Buffer
PBS pH 7.4
Biological Activity
Endogenous alpha-synuclein phosphorylation. 100 uM alpha synuclein protein monomer seeded with 10 nM alpha synuclein protein aggregate in 25 uM Thioflavin T (PBS pH 7.4, 100 ul reaction volume) generated an increased fluorescence intensity after incubation at 37 degree C with shaking at 600 rpm for 24 hours. Fluorescence was measured by excitation at 450 nm and emission at 485 nm on a Molecular Devices Gemini XPS microplate reader.
Tag Information
No tag

Product Categories/Family for Snca active protein

Protein; Neuroscience; Neurodegeneration; Alzheimer's Disease; Tangles & Tau; Neuroscience; Neurodegeneration; Parkinson's Disease; Synuclein
Applications Tested/Suitable for Snca active protein
Western Blot (WB), SDS-PAGE, In vivo assay, In vitro assay

Testing Data of Snca active protein

Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers. Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate is combined with 100 uM of active alpha Synuclein monomer, as compared to active alpha Synuclein aggregate and active alpha Synuclein monomer alone. Thioflavin T ex = 450 nm, em = 485 nm.
SNCA Active Protein – Cat# MBS8001848

SDS-Page of Snca active protein

SDS-PAGE of ~14 kDa Active Mouse Recombinant Alpha Synuclein Protein Aggregate. Lane 1: Molecular Weight Ladder (MW). Lane 2: Active Alpha Synuclein Protein Aggregate (2 ug).
SNCA Active Protein, SDS-Page – Cat# MBS8001848

Product References and Citations for Snca active protein

1. "Genetics Home Reference: SNCA". US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

Other Notes

Small volumes of Snca active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Snca purchase

MBS8001848 is an active protein targeting Snca. Also known as Alpha Synuclein Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Snca. It may not necessarily be applicable to this product.

NCBI GI #
109638747
NCBI GeneID
20617
NCBI Accession #
NP_001035916.1
UniProt Primary Accession #
O55042
UniProt Secondary Accession #
Q3U130; Q9CXF8; Q9EQC3; Q9QUR3
UniProt Related Accession #
O55042
GenBank Nucleotide #
NM_001042451.2
NCBI Official Full Name
alpha-synuclein
NCBI Official Synonym Full Names
synuclein, alpha
NCBI Official Symbol
Snca
NCBI Official Synonym Symbols
NACP; alphaSYN; alpha-Syn
UniProt Protein Name
Alpha-synuclein
UniProt Synonym Protein Names
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Protein Family
Alpha-synuclein
UniProt Gene Name
Snca
UniProt Synonym Gene Names
Syn; NACP
NCBI Protein Information
alpha-synuclein

UniProt Comments for Snca

May be involved in the regulation of dopamine release and transport.

Research Articles on Snca

1. alpha-synuclein levels can be reduced in neurons without impairing (or improving) mitochondrial bioenergetics or distribution

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Snca active protein

 Reference Product  PubMed Publications
 Park2 active protein  >1228 publications with Snca and Park2
 Lrrk2 active protein  >197 publications with Snca and Lrrk2
 Park7 active protein  >67 publications with Snca and Park7
 Sncaip active protein  >35 publications with Snca and Sncaip
 App active protein  >27 publications with Snca and App
 Slc6a3 active protein  >16 publications with Snca and Slc6a3
 Fyn active protein  >4 publications with Snca and Fyn
 Klk6 active protein  >1 publications with Snca and Klk6

Pathways associated with Snca active protein

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram

Diseases associated with Snca active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1519 publications with Snca and Nervous System Diseases
 Brain Diseases Antibodies  >1496 publications with Snca and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1472 publications with Snca and Neurodegenerative Diseases
 Movement Disorders Antibodies  >1321 publications with Snca and Movement Disorders
 Parkinsonian Disorders Antibodies  >1215 publications with Snca and Parkinsonian Disorders
 Parkinson Disease Antibodies  >1176 publications with Snca and Parkinson Disease
 Lewy Body Disease Antibodies  >336 publications with Snca and Lewy Body Disease
 Disease Models, Animal Antibodies  >219 publications with Snca and Disease Models, Animal
 Nerve Degeneration Antibodies  >182 publications with Snca and Nerve Degeneration
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >70 publications with Snca and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT

Organs/Tissues associated with Snca active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1083 publications with Snca and Brain
 Embryonic Tissue Antibodies  >29 publications with Snca and Embryonic Tissue
 Eye Antibodies  >19 publications with Snca and Eye
 Skin Antibodies  >15 publications with Snca and Skin
 Liver Antibodies  >11 publications with Snca and Liver
 Bone Antibodies  >11 publications with Snca and Bone
 Lung Antibodies  >10 publications with Snca and Lung
 Sympathetic Ganglion Antibodies  >6 publications with Snca and Sympathetic Ganglion
 Olfactory Mucosa Antibodies  >3 publications with Snca and Olfactory Mucosa
 Prostate Antibodies  >3 publications with Snca and Prostate
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