Cytochrome C Oxidase Subunit III (COX3) ELISA Kit for Human

Function: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit. From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place. The complex also functions as a proton pump. Ref.1 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8

Cofactor: Binds 2 heme C groups per subunit. Ref.4 Ref.6 Ref.7

Pathway: Energy metabolism; oxidative phosphorylation.

Subunit structure: Component of the cbb3-type cytochrome c oxidase at least composed of FixN, FixO, FixQ and FixP. Ref.4 Ref.5 Ref.6

Subcellular location: Cell inner membrane; Single-pass membrane protein Ref.1 Ref.7.

Disruption phenotype: Microaerobically grown cells show 38% decrease in cytochrome c oxadase complex activity. Between 0-5% nitrogen fixing activity of the nitrogenase in root nodules when in symbiosis with soybean. Ref.5

Sequence similarities: Belongs to the CcoP / FixP family.Contains 2 cytochrome c domains.

Mass spectrometry: Molecular mass is 32130 Da from positions 1 - 290. Determined by ESI. Ref.6