Adenosine Receptor A1 (ADORA1) Rat Recombinant Protein

ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; Endoplasmic reticulum; Apoptosis; GPCR, family 1

Cellular Component: basolateral plasma membrane; endoplasmic reticulum; dendrite; postsynaptic density; dendritic spine; integral to membrane; endomembrane system; terminal button; axolemma; presynaptic membrane; asymmetric synapse; postsynaptic membrane; cell soma; presynaptic active zone; plasma membrane; synapse

Molecular Function: protein binding; G-protein-coupled receptor binding; protein heterodimerization activity; G-protein beta/gamma-subunit binding; adenosine receptor activity, G-protein coupled; purine nucleoside binding; phospholipase C activity; heterotrimeric G-protein binding

Biological Process: negative regulation of circadian sleep/wake cycle, non-REM sleep; relaxation of vascular smooth muscle; negative regulation of glutamate secretion; activation of MAPKK activity; negative regulation of heart contraction; regulation of vasodilation; negative regulation of hormone secretion; positive regulation of potassium ion transport; negative regulation of circadian sleep/wake cycle, sleep; regulation of synaptic plasticity; neurological control of breathing; positive regulation of peptide secretion; thermoregulation; positive regulation of protein amino acid dephosphorylation; negative regulation of cell proliferation; regulation of glomerular filtration; negative regulation of lipid catabolic process; positive regulation of nucleoside transport; positive regulation of epidermal growth factor receptor activity; negative regulation of vasodilation; negative regulation of blood pressure; negative regulation of synaptic transmission, GABAergic; detection of temperature stimulus involved in sensory perception of pain; protein targeting to membrane; adenosine receptor signaling pathway; negative regulation of neurotrophin production; negative regulation of synaptic transmission, glutamatergic; negative regulation of acute inflammatory response; negative regulation of leukocyte migration; G-protein coupled receptor protein signaling pathway; negative regulation of inflammatory response; response to hypoxia; regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; cognition; regulation of excitatory postsynaptic membrane potential; lipid catabolic process; positive regulation of blood pressure; negative regulation of apoptosis